10037-1-Ig

antibody from Proteintech Group

Targeting: XIAP API3, BIRC4, hILP, ILP-1

Provider product page for 10037-1-Ig

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [40]
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Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [1]

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Product number: 10037-1-Ig - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10037-1-Ig, RRID:AB_2215009
Product name: XIAP antibody
Antibody type: Polyclonal
Description: KD/KO validated XIAP antibody (Cat. #10037-1-Ig) is a rabbit polyclonal antibody that shows reactivity with human, rat, mouse and has been validated for the following applications: IHC, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

XIAP protein structure - 10037-1-Ig shown in red.

Submitted references XIAP-mediated degradation of IFT88 disrupts HSC cilia to stimulate HSC activation and liver fibrosis.

Hong R, Tan Y, Tian X, Huang Z, Wang J, Ni H, Yang J, Bu W, Yang S, Li T, Yu F, Zhong W, Sun T, Wang X, Li D, Liu M, Yang Y, Zhou J
EMBO reports 2024 Mar;25(3):1055-1074

DAB2IP Is a Bifunctional Tumor Suppressor That Regulates Wild-Type RAS and Inflammatory Cascades in KRAS Mutant Colon Cancer.

Miller AL, Perurena N, Gardner A, Hinoue T, Loi P, Laird PW, Cichowski K
Cancer research 2023 Jun 2;83(11):1800-1814

Aspirin modulates succinylation of PGAM1K99 to restrict the glycolysis through NF-κB/HAT1/PGAM1 signaling in liver cancer.

Wang YF, Zhao LN, Geng Y, Yuan HF, Hou CY, Zhang HH, Yang G, Zhang XD
Acta pharmacologica Sinica 2023 Jan;44(1):211-220

Amano S, Hirashita T, Kawano Y, Nishida H, Orimoto H, Kawamura M, Kawasaki T, Masuda T, Endo Y, Ohta M, Daa T, Inomata M
World journal of surgical oncology 2023 Dec 12;21(1):381

Number 2 Feibi Recipe Inhibits H(2)O(2)-Mediated Oxidative Stress Damage of Alveolar Epithelial Cells by Regulating the Balance of Mitophagy/Apoptosis.

Gu X, Long Q, Wei W, Tong J, Li Z, Zhang Z, Jiao Y
Frontiers in pharmacology 2022;13:830554

Hydrogen gas promotes apoptosis of lung adenocarcinoma A549 cells through X-linked inhibitor of apoptosis and baculoviral inhibitor of apoptosis protein repeat-containing 3.

Zhang Y, Chen G, Yan Z, Wang L, Wang D
Journal of cancer research and therapeutics 2022 Sep;18(5):1380-1386

Targeting dual-specificity tyrosine phosphorylation-regulated kinase 2 with a highly selective inhibitor for the treatment of prostate cancer.

Yuan K, Li Z, Kuang W, Wang X, Ji M, Chen W, Ding J, Li J, Min W, Sun C, Ye X, Lu M, Wang L, Ge H, Jiang Y, Hao H, Xiao Y, Yang P
Nature communications 2022 May 25;13(1):2903

Potential for reversing miR-634-mediated cytoprotective processes to improve efficacy of chemotherapy against oral squamous cell carcinoma.

Tran PX, Inoue J, Harada H, Inazawa J
Molecular therapy oncolytics 2022 Mar 17;24:897-908

PBK drives PARP inhibitor resistance through the TRIM37/NFκB axis in ovarian cancer.

Ma H, Qi G, Han F, Peng J, Yuan C, Kong B
Experimental & molecular medicine 2022 Jul;54(7):999-1010

4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis.

Li W, Huang BS, Xiong YY, Yang LJ, Wu LX
Cancer cell international 2022 Jan 18;22(1):32

VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, induces cell cycle arrest and apoptosis in breast cancer cells by inhibiting the Wnt/β-catenin pathway.

Li H, Dang C, Tai X, Xue L, Meng Y, Ma S, Zhang J
Scientific reports 2021 Jul 22;11(1):14985

Cellular FLICE-like inhibitory protein (cFLIP) critically maintains apoptotic resistance in human lens epithelial cells.

Huangfu J, Hao C, Wei Z, Wormstone IM, Yan H, Fan X
Cell death & disease 2021 Apr 9;12(4):386

Brevilin A Inhibits STAT3 Signaling and Induces ROS-Dependent Apoptosis, Mitochondrial Stress and Endoplasmic Reticulum Stress in MCF-7 Breast Cancer Cells.

Saleem MZ, Nisar MA, Alshwmi M, Din SRU, Gamallat Y, Khan M, Ma T
OncoTargets and therapy 2020;13:435-450

miR-431-5p regulates cell proliferation and apoptosis in fibroblast-like synoviocytes in rheumatoid arthritis by targeting XIAP.

Wang Y, Zhang K, Yuan X, Xu N, Zhao S, Hou L, Yang L, Zhang N
Arthritis research & therapy 2020 Oct 6;22(1):231

Extracellular Vesicle Delivery of TRAIL Eradicates Resistant Tumor Growth in Combination with CDK Inhibition by Dinaciclib.

Ke C, Hou H, Li J, Su K, Huang C, Lin Y, Lu Z, Du Z, Tan W, Yuan Z
Cancers 2020 May 4;12(5)

Effect of epiberberine from Coptis chinensis Franch on inhibition of tumor growth in MKN-45 xenograft mice.

Yu M, Ren L, Liang F, Zhang Y, Jiang L, Ma W, Li C, Li X, Ye X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 May 17;76:153216

Regorafenib suppresses epidermal growth factor receptor signaling-modulated progression of colorectal cancer.

Liu YC, Tsai JJ, Weng YS, Hsu FT
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Aug;128:110319

Synergism of cisplatin-oleanolic acid co-loaded calcium carbonate nanoparticles on hepatocellular carcinoma cells for enhanced apoptosis and reduced hepatotoxicity.

Khan MW, Zhao P, Khan A, Raza F, Raza SM, Sarfraz M, Chen Y, Li M, Yang T, Ma X, Xiang G
International journal of nanomedicine 2019;14:3753-3771

The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.

Tang W, Zhou W, Xiang L, Wu X, Zhang P, Wang J, Liu G, Zhang W, Peng Y, Huang X, Cai J, Bai Y, Bai L, Zhu W, Gu H, Xiong J, Ye C, Li A, Liu S, Wang J
Nature communications 2019 Feb 8;10(1):663

Proscillaridin A Promotes Oxidative Stress and ER Stress, Inhibits STAT3 Activation, and Induces Apoptosis in A549 Lung Adenocarcinoma Cells.

Maryam A, Mehmood T, Yan Q, Li Y, Khan M, Ma T
Oxidative medicine and cellular longevity 2018;2018:3853409

Brevilin A promotes oxidative stress and induces mitochondrial apoptosis in U87 glioblastoma cells.

Wang J, Li M, Cui X, Lv D, Jin L, Khan M, Ma T
OncoTargets and therapy 2018;11:7031-7040

Anti-breast-Cancer Activity Exerted by β-Sitosterol-d-glucoside from Sweet Potato via Upregulation of MicroRNA-10a and via the PI3K-Akt Signaling Pathway.

Xu H, Li Y, Han B, Li Z, Wang B, Jiang P, Zhang J, Ma W, Zhou D, Li X, Ye X
Journal of agricultural and food chemistry 2018 Sep 19;66(37):9704-9718

An ATM/TRIM37/NEMO Axis Counteracts Genotoxicity by Activating Nuclear-to-Cytoplasmic NF-κB Signaling.

Wu G, Song L, Zhu J, Hu Y, Cao L, Tan Z, Zhang S, Li Z, Li J
Cancer research 2018 Nov 15;78(22):6399-6412

Role of Daucosterol Linoleate on Breast Cancer: Studies on Apoptosis and Metastasis.

Han B, Jiang P, Liu W, Xu H, Li Y, Li Z, Ma H, Yu Y, Li X, Ye X
Journal of agricultural and food chemistry 2018 Jun 20;66(24):6031-6041

Targeting inhibitors of apoptosis proteins suppresses medulloblastoma cell proliferation via G2/M phase arrest and attenuated neddylation of p21.

Chen SM, Lin TK, Tseng YY, Tu CH, Lui TN, Huang SF, Hsieh LL, Li YY
Cancer medicine 2018 Aug;7(8):3988-4003

PCSK9 regulates apoptosis in human lung adenocarcinoma A549 cells via endoplasmic reticulum stress and mitochondrial signaling pathways.

Xu X, Cui Y, Cao L, Zhang Y, Yin Y, Hu X
Experimental and therapeutic medicine 2017 May;13(5):1993-1999

Phloretin induces apoptosis of human esophageal cancer via a mitochondria-dependent pathway.

Duan H, Wang R, Yan X, Liu H, Zhang Y, Mu D, Han J, Li X
Oncology letters 2017 Dec;14(6):6763-6768

Blockade of Inhibitors of Apoptosis Proteins in Combination with Conventional Chemotherapy Leads to Synergistic Antitumor Activity in Medulloblastoma and Cancer Stem-Like Cells.

Chen SM, Li YY, Tu CH, Salazar N, Tseng YY, Huang SF, Hsieh LL, Lui TN
PloS one 2016;11(8):e0161299

BG-4, a novel anticancer peptide from bitter gourd (Momordica charantia), promotes apoptosis in human colon cancer cells.

Dia VP, Krishnan HB
Scientific reports 2016 Sep 15;6:33532

The putative tumor activator ARHGEF3 promotes nasopharyngeal carcinoma cell pathogenesis by inhibiting cellular apoptosis.

Liu TH, Zheng F, Cai MY, Guo L, Lin HX, Chen JW, Liao YJ, Kung HF, Zeng YX, Xie D
Oncotarget 2016 May 3;7(18):25836-48

PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways.

Yao Z, Sun B, Hong Q, Yan J, Mu D, Li J, Sheng H, Guo H
Drug design, development and therapy 2015;9:5911-23

CRNDE affects the malignant biological characteristics of human glioma stem cells by negatively regulating miR-186.

Zheng J, Li XD, Wang P, Liu XB, Xue YX, Hu Y, Li Z, Li ZQ, Wang ZH, Liu YH
Oncotarget 2015 Sep 22;6(28):25339-55

Oxaliplatin triggers necrosis as well as apoptosis in gastric cancer SGC-7901 cells.

Wu P, Zhu X, Jin W, Hao S, Liu Q, Zhang L
Biochemical and biophysical research communications 2015 May 1;460(2):183-90

Trichothecin induces cell death in NF-κB constitutively activated human cancer cells via inhibition of IKKβ phosphorylation.

Su J, Zhao P, Kong L, Li X, Yan J, Zeng Y, Li Y
PloS one 2013;8(8):e71333

Overexpression of the truncated form of Livin reveals a complex interaction with caspase-3.

Liu GH, Wang C, Ding ZY
International journal of oncology 2013 Jun;42(6):2037-45

Caspases and inhibitor of apoptosis proteins in cutaneous and mucosal melanoma: expression profile and clinicopathologic significance.

Chen N, Gong J, Chen X, Meng W, Huang Y, Zhao F, Wang L, Zhou Q
Human pathology 2009 Jul;40(7):950-6

Expression patterns and prognostic significance of inhibitor of apoptosis proteins in adenoid cystic carcinoma and pleomorphic adenoma of lachrymal gland.

Liao Y, Zeng H, Wang X, Huang Y, Chen N, Ge B, Tang L, Luo Q
Experimental eye research 2009 Jan;88(1):4-11

Survivin knockdown combined with apoptin overexpression inhibits cell growth significantly.

Liu Q, Fu H, Xing R, Tie Y, Zhu J, Sun Z, Zheng X
Cancer biology & therapy 2008 Jul;7(7):1053-60

Apoptosis and proliferation markers in diffusely infiltrating astrocytomas: profiling of 17 molecules.

Liu X, Chen N, Wang X, He Y, Chen X, Huang Y, Yin W, Zhou Q
Journal of neuropathology and experimental neurology 2006 Sep;65(9):905-13

Survivin nuclear labeling index: a superior biomarker in superficial urothelial carcinoma of human urinary bladder.

Yin W, Chen N, Zhang Y, Zeng H, Chen X, He Y, Wang X, Zhou Q
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2006 Nov;19(11):1487-97

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HepG2 cells were subjected to SDS PAGE followed by western blot with 10037-1-Ig(XIAP antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of MCF-7 cells, using XIAP antibody 10037-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human pancreas cancer using 10037-1-Ig(XIAP antibody) at dilution of 1:200 (under 40x lens)
Sample type: tissue