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- Antigen structure
- References [11]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- ABIN151733 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) antibody
- Antibody type
- Polyclonal
- Description
- Unpurified
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Vial size
- 0.1 mL
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
- Handling
- Avoid freeze-thaw cycles
Submitted references The triterpenoid corosolic acid blocks transformation and epigenetically reactivates Nrf2 in TRAMP-C1 prostate cells.
Regulation of human RNA polymerase III transcription by DNMT1 and DNMT3a DNA methyltransferases.
Combined inhibition of DNA methyltransferase and histone deacetylase restores caspase-8 expression and sensitizes SCLC cells to TRAIL.
The depletion of DNA methyltransferase-1 and the epigenetic effects of 5-aza-2'deoxycytidine (decitabine) are differentially regulated by cell cycle progression.
SALL3 interacts with DNMT3A and shows the ability to inhibit CpG island methylation in hepatocellular carcinoma.
Loss of pericentromeric DNA methylation pattern in human glioblastoma is associated with altered DNA methyltransferases expression and involves the stem cell compartment.
Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells.
Dynamic expression of DNMT3a and DNMT3b isoforms during male germ cell development in the mouse.
DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells.
Identification and characterization of alternatively spliced variants of DNA methyltransferase 3a in mammalian cells.
An essential role for DNA methyltransferase DNMT3B in cancer cell survival.
Yang J, Wu R, Li W, Gao L, Yang Y, Li P, Kong AN
Molecular carcinogenesis 2018 Apr;57(4):512-521
Molecular carcinogenesis 2018 Apr;57(4):512-521
Regulation of human RNA polymerase III transcription by DNMT1 and DNMT3a DNA methyltransferases.
Selvakumar T, Gjidoda A, Hovde SL, Henry RW
The Journal of biological chemistry 2012 Mar 2;287(10):7039-50
The Journal of biological chemistry 2012 Mar 2;287(10):7039-50
Combined inhibition of DNA methyltransferase and histone deacetylase restores caspase-8 expression and sensitizes SCLC cells to TRAIL.
Kaminskyy VO, Surova OV, Vaculova A, Zhivotovsky B
Carcinogenesis 2011 Oct;32(10):1450-8
Carcinogenesis 2011 Oct;32(10):1450-8
The depletion of DNA methyltransferase-1 and the epigenetic effects of 5-aza-2'deoxycytidine (decitabine) are differentially regulated by cell cycle progression.
Al-Salihi M, Yu M, Burnett DM, Alexander A, Samlowski WE, Fitzpatrick FA
Epigenetics 2011 Aug;6(8):1021-8
Epigenetics 2011 Aug;6(8):1021-8
SALL3 interacts with DNMT3A and shows the ability to inhibit CpG island methylation in hepatocellular carcinoma.
Shikauchi Y, Saiura A, Kubo T, Niwa Y, Yamamoto J, Murase Y, Yoshikawa H
Molecular and cellular biology 2009 Apr;29(7):1944-58
Molecular and cellular biology 2009 Apr;29(7):1944-58
Loss of pericentromeric DNA methylation pattern in human glioblastoma is associated with altered DNA methyltransferases expression and involves the stem cell compartment.
Fanelli M, Caprodossi S, Ricci-Vitiani L, Porcellini A, Tomassoni-Ardori F, Amatori S, Andreoni F, Magnani M, De Maria R, Santoni A, Minucci S, Pelicci PG
Oncogene 2008 Jan 10;27(3):358-65
Oncogene 2008 Jan 10;27(3):358-65
Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells.
Reynolds PA, Sigaroudinia M, Zardo G, Wilson MB, Benton GM, Miller CJ, Hong C, Fridlyand J, Costello JF, Tlsty TD
The Journal of biological chemistry 2006 Aug 25;281(34):24790-802
The Journal of biological chemistry 2006 Aug 25;281(34):24790-802
Dynamic expression of DNMT3a and DNMT3b isoforms during male germ cell development in the mouse.
La Salle S, Trasler JM
Developmental biology 2006 Aug 1;296(1):71-82
Developmental biology 2006 Aug 1;296(1):71-82
DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells.
Robert MF, Morin S, Beaulieu N, Gauthier F, Chute IC, Barsalou A, MacLeod AR
Nature genetics 2003 Jan;33(1):61-5
Nature genetics 2003 Jan;33(1):61-5
Identification and characterization of alternatively spliced variants of DNA methyltransferase 3a in mammalian cells.
Weisenberger DJ, Velicescu M, Preciado-Lopez MA, Gonzales FA, Tsai YC, Liang G, Jones PA
Gene 2002 Sep 18;298(1):91-9
Gene 2002 Sep 18;298(1):91-9
An essential role for DNA methyltransferase DNMT3B in cancer cell survival.
Beaulieu N, Morin S, Chute IC, Robert MF, Nguyen H, MacLeod AR
The Journal of biological chemistry 2002 Aug 2;277(31):28176-81
The Journal of biological chemistry 2002 Aug 2;277(31):28176-81
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Supportive validation
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