DNMT3A

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016]

Description

DNA methyltransferase 3 alpha

Protein family

Cancer-related genes, Disease related genes, Enzymes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Protein evidence (Peptideatlas), Transcription factors

Chromosome

2:p23.3 (25227855 - 25342590)

Ensembl ID

ENSG00000119772  (ver. 99.38)

Orthologs

Mouse Dnmt3a: ENSMUSG00000020661

UniProt

Q9Y6K1

neXtProt

NX_Q9Y6K1

Human splice variants
Mouse splice variants