DNMT3A

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Description

DNA (cytosine-5-)-methyltransferase 3 alpha

Protein family

Cancer-related genes, Disease related genes, Enzymes, Mapped to UniProt SWISS-PROT, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014), Transcription factors

Chromosome

2:p23.3 (25227855 - 25342590)

Ensembl ID

ENSG00000119772  (ver. 84.38)

Orthologs

Mouse Dnmt3a: ENSMUSG00000020661

UniProt

Q9Y6K1

neXtProt

NX_Q9Y6K1

Human splice variants
Mouse splice variants