TYROBP

gene product
DAP12, KARAP, PLO-SL, PLOSL
This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
266 antibodies from 32 providers.

Antibody properties

General

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
97 antibodies
Atlas Antibodies
1 antibody
Novus Biologicals
12 antibodies
Biorbyt
18 antibodies
NovoPro Bioscience Inc.
2 antibodies
Acris Antibodies GmbH
4 antibodies
OriGene
6 antibodies
R&D Systems
9 antibodies
Abgent
3 antibodies
Invitrogen Antibodies
5 antibodies
Affinity Biosciences
1 antibody
Aviva Systems Biology
1 antibody
GeneTex
5 antibodies
LifeSpan BioSciences, Inc.
23 antibodies
Abnova Corporation
3 antibodies
Bioworld Technology, Inc
1 antibody
ProSci
1 antibody
Cell Signaling Technology, Inc
1 antibody
Everest Biotech
1 antibody
Creative Biolabs
7 antibodies
MyBioSource
6 antibodies
Creative Diagnostics
5 antibodies
RabMAbs
2 antibodies
Santa Cruz Biotechnology
1 antibody
United States Biological
37 antibodies
Miltenyi Biotec
4 antibodies
St John's Laboratory
2 antibodies
Exalpha Biologicals, Inc.
1 antibody
RayBiotech, Inc.
1 antibody
EMD Millipore
2 antibodies
GenWay
2 antibodies
Sigma-Aldrich
2 antibodies