Tissue expression
Cell line expression

TYROBP

gene product
DAP12, KARAP, PLO-SL, PLOSL 
This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]
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299 antibodies from 37 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
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ProSci
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Everest Biotech
1 antibody
MyBioSource
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Creative Diagnostics
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Miltenyi Biotec
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Abbexa
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RayBiotech, Inc.
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EMD Millipore
2 antibodies
GenWay
2 antibodies
MilliporeSigma / Merck KGaA
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