11114-1-AP

antibody from Proteintech Group

Targeting: TAP1 ABCB2, D6S114E, PSF1, RING4

Provider product page for 11114-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [42]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 11114-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11114-1-AP, RRID:AB_2200201
Product name: TAP1 antibody
Antibody type: Polyclonal
Description: KD/KO validated TAP1 antibody (Cat. #11114-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

TAP1 protein structure - 11114-1-AP shown in red.

Submitted references RNF26 regulating tumor immunogenicity of hepatocellular carcinoma by degrading GRP78 and instigating ER stress.

Luo J, Zhuo H, Zheng M, Fang Y, Wang X, Jin Y, Li Y, Du S, Wang J, Xue C, Jiang R, Li G
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2026 May;86:101375

Integrated Transcriptomic Analysis Identifies TAP1 as a Key Regulator of PANoptosis in Diabetic Kidney Disease Tubular Injury.

Chen Q, He H, Wang G, Huang L, Yang J, Sun Y, Zhang Z, Liao X
Inflammation 2026 Jan 22;49(1):80

Low expression of ALOX15B modulates immunosuppressive tumor microenvironment in diffuse large B-cell lymphoma via the TAP1/MHC-I axis.

Wang L, Liu J, Shang Y, Zhang L, Zhang M, Fu D, Cheng S, Xu P, Anegeli E, Bousquet G, Fang Y, Liu Y, Zhao WL
Journal of experimental & clinical cancer research : CR 2026 Jan 12;45(1):43

p53 regulates early mucosal immunity via antigen presentation in zebrafish intestine post-SVCV vaccination.

Zhao Z, Wei XF, Zhao L, Xia JY, Li YY, Jia YJ, Zhu B
Cell communication and signaling : CCS 2026 Feb 17;24(1)

Modulation of rhesus macaque killer cell immunoglobulin-like receptor-MHC I interactions by simian immunodeficiency virus peptides.

Sandstrom K, Anderson JL, Katz JE, Wetzel M, Klenchin VA, Evans DT
Journal of immunology (Baltimore, Md. : 1950) 2026 Apr 15;215(4)

TAP1 promotes immune escape by activating JNK/STAT1/PD-L1 signaling in EBV-associated gastric cancer.

Shan W, Li G, Zhang H, Zhang R, Liu J, Gao L, Li Y, Fan L, Yang C, Liu J
Molecular and cellular biochemistry 2025 Oct;480(10):5429-5446

Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways.

Pachano T, Leng H, Dugied G, Tribble T, Loubiere V, Rauh F, Lee Y, Schleiffer A, Young V, Weller B, Lyons EA, Hass MR, Kottayan LC, Weirauch MT, Fuxman Bass JI, Newton HJ, Ensminger AW, Braun PF, Schramek D, Stark A, Taipale M
bioRxiv : the preprint server for biology 2025 Nov 17;

STING agonist-based ER-targeting molecules boost antigen cross-presentation.

Wang X, Huang Z, Xing L, Shang L, Jiang J, Deng C, Yu W, Peng L, Yang H, Zheng X, Liu X, Yang H, Chen Y, Li Y, Liu J, Xie X, Xu W, Xia X, Liu Z, Liu W, Jiang S, Zeng Y, Lu L, Wang J
Nature 2025 May;641(8061):202-210

Targeting Annexin A2 to reactivate tumor-associated antigens presentation and relieve immune tolerance in liver cancer.

Tang Y, Yang J, Shen Q, Gao Z, Wu M, Wu C, Du J, Li M, Ling C, Lu F, Chai Y, Dong X, Qian J, Li C, Xie F, Guo Z, Shen H, Wang D
Journal for immunotherapy of cancer 2025 Jun 26;13(6)

Antitumor efficacy of intermittent low-dose erlotinib plus sulindac via MHC upregulation and remodeling of the immune cell niche.

Tripathi C, Tovar Perez JE, Kapoor S, Muhsin A, Dashwood WM, Demirhan Y, Demirhan M, Shapiro A, Mohammed A, Sei S, Thompson J, Zaheer M, Sinha KM, Brown PH, Savage MI, Vilar E, Rajendran P, Dashwood RH
International journal of cancer 2025 Jul 15;157(2):355-370

Targeting EGFR-binding protein SLC7A11 enhancing antitumor immunity of T cells via inducing MHC-I antigen presentation in nasopharyngeal carcinoma.

Wang H, Fan S, Zhan Y, Xu Y, Du Y, Luo J, Zang H, Peng S, Wang W
Cell death & disease 2025 Jan 16;16(1):21

Neuronal hyperactivity becomes mTORC1 independent due to transcriptional changes in tuberous sclerosis complex disease models.

Afshar-Saber W, Ruiz JF, Gisser I, Yang Z, Mehendale L, Teaney NA, Hobson R, Glass MR, Pham TT, Bainbridge E, Sahin M, Winden KD
Cell reports 2025 Dec 23;44(12):116664

Reversible downregulation of HLA class I in adenoid cystic carcinoma.

Li A, Gonda BL, Codd EM, von Paternos A, Mitchell DR, Herrmann MD, Kalyan P, Flynn SE, Dzu TQ, Gao C, Zhang E, Mendel JJ, Thierauf JC, Sadow PM, Denize T, Yang D, Fintelmann FJ, Fordham JA, Merkin RD, Bhan AK, Huang YC, Raizer J, Faquin WC, Faden DL, Gao X, Park JC, Wirth LJ, Kaluziak ST, Iafrate AJ
Journal for immunotherapy of cancer 2025 Apr 20;13(4)

Spatial transcriptomic analysis of amelanotic acral melanoma versus pigmented acral melanoma reveals distinct molecular determinants.

Choi ME, Choi EJ, Lee JH, Won CH, Chang SE, Lee MW, Lee WJ
The British journal of dermatology 2024 Sep 18;191(4):580-591

TET2 promotes tumor antigen presentation and T cell IFN-γ, which is enhanced by vitamin C.

Cheng M, Chu AKY, Li Z, Yang S, Smith MD, Zhang Q, Brown NG, Marzluff WF, Bardeesy N, Milner JJ, Welch JD, Xiong Y, Baldwin AS
JCI insight 2024 Nov 22;9(22)

Identification of TAP1 as a T-cell related therapeutic target in gastric cancer by mediating oxalipliatin-related synergistic enhancement of immunotherapy.

Zhao Y, Liu Z, Deng K, Qu H, Zhang Q, Zhou P, Yang M, Yang X, Wang H, Li R, Xia J
International immunopharmacology 2024 May 10;132:111998

The herpesvirus UL49.5 protein hijacks a cellular C-degron pathway to drive TAP transporter degradation.

Wąchalska M, Riepe C, Ślusarz MJ, Graul M, Borowski LS, Qiao W, Foltyńska M, Carette JE, Bieńkowska-Szewczyk K, Szczesny RJ, Kopito RR, Lipińska AD
Proceedings of the National Academy of Sciences of the United States of America 2024 Mar 12;121(11):e2309841121

Immunomodulatory effects of antiangiogenic tyrosine kinase inhibitors in renal cell carcinoma models: Impact on following anti-PD-1 treatments.

Fumarola C, La Monica S, Bonelli M, Zoppi S, Alfieri R, Galetti M, Gnetti L, Campanini N, Pozzi G, Cavazzoni A, Mazzaschi G, Silini EM, Buti S, Petronini PG
Biochemical pharmacology 2024 Aug;226:116397

The herpesvirus UL49.5 protein hijacks a cellular C-degron pathway to drive TAP transporter degradation.

Wąhalska M, Riepe C, Ślusarz MJ, Graul M, Borowski LS, Qiao W, Foltynska M, Carette JE, Bieńkowska-Szewczyk K, Szczesny RJ, Kopito RR, Lipińska AD
bioRxiv : the preprint server for biology 2023 Sep 27;

The proteome and transcriptome of stress granules and P bodies during human T lymphocyte activation.

Curdy N, Lanvin O, Cerapio JP, Pont F, Tosolini M, Sarot E, Valle C, Saint-Laurent N, Lhuillier E, Laurent C, Fournié JJ, Franchini DM
Cell reports 2023 Mar 28;42(3):112211

The N-terminal Proline Hinge Motif Controls the Structure of Bovine Herpesvirus 1-encoded Inhibitor of the Transporter Associated with Antigen Processing Required for its Immunomodulatory Function.

Graul M, Karska N, Wąchalska M, Krupa P, Ślusarz MJ, Lubocki M, Bieńkowska-Szewczyk K, Rodziewicz-Motowidło S, Sieradzan AK, Lipińska AD
Journal of molecular biology 2023 Mar 1;435(5):167964

Pan-cancer analysis: predictive role of TAP1 in cancer prognosis and response to immunotherapy.

Tu Z, Li K, Ji Q, Huang Y, Lv S, Li J, Wu L, Huang K, Zhu X
BMC cancer 2023 Feb 9;23(1):133

ANGPTL2-mediated epigenetic repression of MHC-I in tumor cells accelerates tumor immune evasion.

Kadomatsu T, Hara C, Kurahashi R, Horiguchi H, Morinaga J, Miyata K, Kurano S, Kanemaru H, Fukushima S, Araki K, Baba M, Linehan WM, Kamba T, Oike Y
Molecular oncology 2023 Dec;17(12):2637-2658

Nintedanib enhances the efficacy of PD-L1 blockade by upregulating MHC-I and PD-L1 expression in tumor cells.

Tu J, Xu H, Ma L, Li C, Qin W, Chen X, Yi M, Sun L, Liu B, Yuan X
Theranostics 2022;12(2):747-766

The expression and prognostic value of transporter 1, ATP binding cassette subfamily B member in clear cell renal cell cancer with experimental validation.

Wang ZD, Tian X, Wang Y, Wang JJ, Ye SQ, Huang YQ, Qu YY, Chang K, Shi GH, Ye DW, Gu CY
Frontiers in oncology 2022;12:1013790

Epigenetic modulation enhances immunotherapy for pancreatic ductal adenocarcinoma.

Li Y, Hong YK, Wang X, Pandit H, Zheng Q, Yu Y, Shi X, Chen Y, Tan M, Pulliam Z, Bhutiani N, Lin A, Badach J, Zhang P, Martin RC
Clinical & translational immunology 2022;11(12):e1430

Antigen peptide transporters are upregulated in squamous cell carcinoma of the oral tongue and show sex-specific associations with survival.

Attaran N, Coates PJ, Zborayova K, Erdogan B, Magan M, Sgaramella N, Nylander K, Gu X
Oncology letters 2022 Nov;24(5):390

Antigen Peptide Transporter 1 (TAP1) Promotes Resistance to MEK Inhibitors in Pancreatic Cancers.

Li B, Feng Y, Hou Q, Fu Y, Luo Y
International journal of molecular sciences 2022 Jun 28;23(13)

Metabolomics of Acute vs. Chronic Spinach Intake in an Apc-Mutant Genetic Background: Linoleate and Butanoate Metabolites Targeting HDAC Activity and IFN-γ Signaling.

Chen YS, Li J, Neja S, Kapoor S, Tovar Perez JE, Tripathi C, Menon R, Jayaraman A, Lee K, Dashwood WM, Wang S, Zhang K, Kobayashi K, Rajendran P, Dashwood R
Cells 2022 Feb 7;11(3)

Proteomic analysis of archival breast cancer clinical specimens identifies biological subtypes with distinct survival outcomes.

Asleh K, Negri GL, Spencer Miko SE, Colborne S, Hughes CS, Wang XQ, Gao D, Gilks CB, Chia SKL, Nielsen TO, Morin GB
Nature communications 2022 Feb 16;13(1):896

Alveolar macrophages instruct CD8(+) T cell expansion by antigen cross-presentation in lung.

Kawasaki T, Ikegawa M, Yunoki K, Otani H, Ori D, Ishii KJ, Kuroda E, Takamura S, Kitabatake M, Ito T, Isotani A, Kawai T
Cell reports 2022 Dec 13;41(11):111828

Noncoding RNA 886 alleviates tumor cellular immunological rejection in host C57BL/C mice.

Ma H, Wang M, Zhou Y, Yang JJ, Wang LY, Yang RH, Wen MJ, Kong L
Cancer medicine 2020 Jul;9(14):5258-5271

microRNA 125a Regulates MHC-I Expression on Esophageal Adenocarcinoma Cells, Associated With Suppression of Antitumor Immune Response and Poor Outcomes of Patients.

Mari L, Hoefnagel SJM, Zito D, van de Meent M, van Endert P, Calpe S, Sancho Serra MDC, Heemskerk MHM, van Laarhoven HWM, Hulshof MCCM, Gisbertz SS, Medema JP, van Berge Henegouwen MI, Meijer SL, Bergman JJGHM, Milano F, Krishnadath KK
Gastroenterology 2018 Sep;155(3):784-798

Molecular Pathways for Immune Recognition of Preproinsulin Signal Peptide in Type 1 Diabetes.

Kronenberg-Versteeg D, Eichmann M, Russell MA, de Ru A, Hehn B, Yusuf N, van Veelen PA, Richardson SJ, Morgan NG, Lemberg MK, Peakman M
Diabetes 2018 Apr;67(4):687-696

Expression of coproporphyrinogen oxidase is associated with detection of upper gastrointestinal carcinomas by 5-aminolevulinic acid-mediated photodynamic diagnosis.

Ogihara K, Isomoto H, Kurumi H, Kanda T, Hashisako M, Tabata K, Ishii H, Ohnita K, Yamaguchi N, Akazawa Y, Matsushima K, Takeshima F, Kunizaki M, Hidaka S, Nanashima A, Fukuoka J, Nagayasu T, Nakao K
Photodiagnosis and photodynamic therapy 2017 Sep;19:15-21

Inducible TAP1 Negatively Regulates the Antiviral Innate Immune Response by Targeting the TAK1 Complex.

Xia Z, Xu G, Yang X, Peng N, Zuo Q, Zhu S, Hao H, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2017 May 1;198(9):3690-3704

IRG1 increases MHC class I level in macrophages through STAT-TAP1 axis depending on NADPH oxidase mediated reactive oxygen species.

Liu X, Wu XP, Zhu XL, Li T, Liu Y
International immunopharmacology 2017 Jul;48:76-83

Characterization of the platelet granule proteome: evidence of the presence of MHC1 in alpha-granules.

Zufferey A, Schvartz D, Nolli S, Reny JL, Sanchez JC, Fontana P
Journal of proteomics 2014 Apr 14;101:130-40

Loss of heterozygosity at 6p21 and HLA class I expression in esophageal squamous cell carcinomas in China.

Zhao X, Sun Q, Tian H, Cong B, Jiang X, Peng C
Asian Pacific journal of cancer prevention : APJCP 2011;12(10):2741-5

Methylation of the promoter of human leukocyte antigen class I in human esophageal squamous cell carcinoma and its histopathological characteristics.

Qifeng S, Bo C, Xingtao J, Chuanliang P, Xiaogang Z
The Journal of thoracic and cardiovascular surgery 2011 Mar;141(3):808-14

The unfolded protein response (UPR)-activated transcription factor X-box-binding protein 1 (XBP1) induces microRNA-346 expression that targets the human antigen peptide transporter 1 (TAP1) mRNA and governs immune regulatory genes.

Bartoszewski R, Brewer JW, Rab A, Crossman DK, Bartoszewska S, Kapoor N, Fuller C, Collawn JF, Bebok Z
The Journal of biological chemistry 2011 Dec 2;286(48):41862-41870

Down-regulation of the antigen processing machinery is linked to a loss of inflammatory response in colorectal cancer.

Kasajima A, Sers C, Sasano H, Jöhrens K, Stenzinger A, Noske A, Buckendahl AC, Darb-Esfahani S, Müller BM, Budczies J, Lehman A, Dietel M, Denkert C, Weichert W
Human pathology 2010 Dec;41(12):1758-69

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HepG2 cells were subjected to SDS PAGE followed by western blot with 11114-1-AP( TAP1 Antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using TAP1 antibody 11114-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
Sample type: cell line