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Protein structure
TAP1
Transporter 1, ATP binding cassette subfamily B memberABCB2, D6S114E, PSF1, RING4
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
Top validated antibodies |
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| Proteintech Group |  11114-1-AP |
24 references | Polyclonal |
WB
EL
ICC
IP
IHC
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| GeneTex | GTX10356 |
1 references | Monoclonal |
WB
EL
ICC
IP
FA
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| Invitrogen Antibodies | 11114-1-AP |
Polyclonal |
WB
ICC
IP
IHC
OA
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| NovoPro Bioscience Inc. | 115850 |
Polyclonal |
WB
EL
ICC
IP
IHC
|
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| Enzo Life Sciences | ADI-CSA-620-E |
1 references | Polyclonal |
WB
ICC
IP
IHC
|
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