ADD2

gene product
ADDB
Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]
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201 antibodies from 25 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
85 antibodies
Abnova Corporation
5 antibodies
Atlas Antibodies
2 antibodies
Santa Cruz Biotechnology
1 antibody
Novus Biologicals
7 antibodies
Biorbyt
16 antibodies
Aviva Systems Biology
3 antibodies
Invitrogen Antibodies
5 antibodies
Affinity Biosciences
1 antibody
NovoPro Bioscience Inc.
1 antibody
OriGene
4 antibodies
LifeSpan BioSciences, Inc.
29 antibodies
Bioworld Technology, Inc
1 antibody
Bethyl Laboratories
3 antibodies
Boster Biological Technology
2 antibodies
Proteintech Group
1 antibody
Acris Antibodies GmbH
3 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
GeneTex
2 antibodies
ProSci
1 antibody
St John's Laboratory
2 antibodies
MyBioSource
5 antibodies
United States Biological
12 antibodies
Creative Diagnostics
6 antibodies
Sigma-Aldrich
3 antibodies