CABT-B9368

antibody from Creative Diagnostics

Targeting: SPTBN2 SCA5

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Antibody Data

Product number

CABT-B9368

Provider

Creative Diagnostics

Product name

Mouse anti-Human ÉÇ-Spectrin II monoclonal antibody, clone 53

Antibody type

Monoclonal

Description

Spectrins are central components of the cytoskeleton that form a scaffold below the plasma membrane. Spectrins contain two subunits, Ï« and ÉÇ, which intertwine to form heterodimers that can self associate into elongated tetramers. Ï«-spectin I and ÉÇ-spectrin I form heterodimers in red blood cells, while nonerythroid mammalian cells contain heterodimers of Ï«-spectin I and II with ÉÇ-spectrin I to V. The structure of spectrins includes a succession of triple-helical repeats alongwith various domains, such as SH3 domain, EF hands, PH domains, and binding domains for ankyrin, actin, band 4.1, and calmodulin. Ï«-spectrin II is a widely expressed non-erythroid Ï«-spectrin that contains an SH3 domain, a calmodulin binding site, and two cleavage sites for proteases, such as calpains and caspase-3. ÉÇ-spectrin II is a widely expressed non-erythroid ÉÇ-spectrin that contains a C-terminal region that interacts with Ï«-spectrins and a PH domain. Ï«-spectrin II and ÉÇ-spectrin II, like many other spectrins, can form heterodimers that can self associate into tetramers, as well as interact with Band 4.1, F-actin, and other proteins near the plasma membrane. This scaffold of cytoskeletal and plasma membrane proteins is critical for the maintenance of cell structure.

Reactivity

Human, Mouse, Rat, Canine

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

53

Vial size

50ug, 150ug

Concentration

250 Ã×g/ml

Storage

Store undiluted at -20°C.