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SPTBN2
Spectrin beta, non-erythrocytic 2SCA5
Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements. [provided by RefSeq, Dec 2009]
Top validated antibodies |
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| NSJ Bioreagents |  V7519 |
Monoclonal |
WB
EL
ICC
IHC
FC
OA
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| Invitrogen Antibodies | 6712-RBM9-P0 |
Monoclonal |
WB
EL
ICC
IHC
FC
OA
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| Novus Biologicals | NBP2-53236-100ug |
Monoclonal |
WB
EL
ICC
IHC
FC
PA
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| LSBio | LS-C142850 |
Polyclonal |
WB
IP
IHC
BN
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| Biorbyt | orb1252199 |
Monoclonal |
WB
EL
ICC
IHC
FC
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