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- References [14]
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- Product number
- 11171-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11171-1-AP, RRID:AB_2171179
- Product name
- PRPF8 antibody
- Antibody type
- Polyclonal
- Description
- PRPF8 antibody (Cat. #11171-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references CUL5 E3 ubiquitin ligase regulates the evasion of bladder cancer cells to CD8+ T cell-mediated killing by inhibiting autophagy.
KAT2A-driven succinylation of SRSF11 enforces spliceosome-mediated RAD52 splicing to promote homologous recombination and radioresistance in hepatocellular carcinoma.
Productive mRNA chromatin escape is promoted by PRMT5 activity.
NLRP7 maintains the genomic stability during early human embryogenesis via mediating alternative splicing.
ZC3H14 facilitates backsplicing by binding to exon-intron boundary and 3' UTR.
Genetic Control of Alternative Splicing and its Distinct Role in Colorectal Cancer Mechanisms.
Species-specific FMRP regulation of RACK1 is critical for prenatal cortical development.
Mechanism of exon ligation by human spliceosome.
Sequence-dependent recruitment of SRSF1 and SRSF7 to intronless lncRNA NKILA promotes nuclear export via the TREX/TAP pathway.
XAB2 depletion induces intron retention in POLR2A to impair global transcription and promote cellular senescence.
Identification of a 35S U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complex intermediate in spliceosome assembly.
An integrative analysis of colon cancer identifies an essential function for PRPF6 in tumor growth.
Rearrangements within human spliceosomes captured after exon ligation.
Breaking up the C complex spliceosome shows stable association of proteins with the lariat intron intermediate.
Gao X, Yu Y, Sun J, Zhao H, You Y, Shi X, Wang K, Hong S, Xiong X, Huang C, Zhang H, Jiang G
PLoS biology 2026 Feb;24(2):e3003647
PLoS biology 2026 Feb;24(2):e3003647
KAT2A-driven succinylation of SRSF11 enforces spliceosome-mediated RAD52 splicing to promote homologous recombination and radioresistance in hepatocellular carcinoma.
Wu J, Yuan J, Liu Z, Zhou Y, Zhang B, Xu Y, Zeng Q, Wu Z, Kong L, Wang J, Zhang B, Yang J, Lv T, Shi Y, Yang J
Signal transduction and targeted therapy 2025 Nov 7;10(1):364
Signal transduction and targeted therapy 2025 Nov 7;10(1):364
Productive mRNA chromatin escape is promoted by PRMT5 activity.
DeAngelo JD, Maron MI, Roth JS, Hegde S, Silverstein AM, Gupta V, Stransky S, Basken J, Azofeifa J, Query CC, Sidoli S, Gamble MJ, Shechter D
Molecular cell 2025 Nov 6;85(21):4016-4031.e9
Molecular cell 2025 Nov 6;85(21):4016-4031.e9
NLRP7 maintains the genomic stability during early human embryogenesis via mediating alternative splicing.
Chen Z, Jiang L, Su M, Zeng Q, Luo P, Chu L
Communications biology 2025 Jan 26;8(1):125
Communications biology 2025 Jan 26;8(1):125
ZC3H14 facilitates backsplicing by binding to exon-intron boundary and 3' UTR.
Li Q, Yang G, Ren B, Liu X, Tang LQ, Shi Q, Shan G, Wang X
Molecular cell 2024 Nov 21;84(22):4314-4333.e9
Molecular cell 2024 Nov 21;84(22):4314-4333.e9
Genetic Control of Alternative Splicing and its Distinct Role in Colorectal Cancer Mechanisms.
Zhang M, Chen C, Lu Z, Cai Y, Li Y, Zhang F, Liu Y, Chen S, Zhang H, Yang S, Gen H, Jiang Y, Ning C, Huang J, Wang W, Fan L, Zhang Y, Jin M, Han J, Xiong Z, Cai M, Liu J, Huang C, Yang X, Xu B, Li H, Li B, Zhu X, Wei Y, Zhu Y, Tian J, Miao X
Gastroenterology 2023 Nov;165(5):1151-1167
Gastroenterology 2023 Nov;165(5):1151-1167
Species-specific FMRP regulation of RACK1 is critical for prenatal cortical development.
Shen M, Sirois CL, Guo Y, Li M, Dong Q, Méndez-Albelo NM, Gao Y, Khullar S, Kissel L, Sandoval SO, Wolkoff NE, Huang SX, Xu Z, Bryan JE, Contractor AM, Korabelnikov T, Glass IA, Doherty D, Birth Defects Research Laboratory, Levine JE, Sousa AMM, Chang Q, Bhattacharyya A, Wang D, Werling DM, Zhao X
Neuron 2023 Dec 20;111(24):3988-4005.e11
Neuron 2023 Dec 20;111(24):3988-4005.e11
Mechanism of exon ligation by human spliceosome.
Zhan X, Lu Y, Zhang X, Yan C, Shi Y
Molecular cell 2022 Aug 4;82(15):2769-2778.e4
Molecular cell 2022 Aug 4;82(15):2769-2778.e4
Sequence-dependent recruitment of SRSF1 and SRSF7 to intronless lncRNA NKILA promotes nuclear export via the TREX/TAP pathway.
Khan M, Hou S, Azam S, Lei H
Nucleic acids research 2021 Jun 21;49(11):6420-6436
Nucleic acids research 2021 Jun 21;49(11):6420-6436
XAB2 depletion induces intron retention in POLR2A to impair global transcription and promote cellular senescence.
Hou S, Qu D, Li Y, Zhu B, Liang D, Wei X, Tang W, Zhang Q, Hao J, Guo W, Wang W, Zhao S, Wang Q, Azam S, Khan M, Zhao H, Zhang L, Lei H
Nucleic acids research 2019 Sep 5;47(15):8239-8254
Nucleic acids research 2019 Sep 5;47(15):8239-8254
Identification of a 35S U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complex intermediate in spliceosome assembly.
Chen Z, Gui B, Zhang Y, Xie G, Li W, Liu S, Xu B, Wu C, He L, Yang J, Yi X, Yang X, Sun L, Liang J, Shang Y
The Journal of biological chemistry 2017 Nov 3;292(44):18113-18128
The Journal of biological chemistry 2017 Nov 3;292(44):18113-18128
An integrative analysis of colon cancer identifies an essential function for PRPF6 in tumor growth.
Adler AS, McCleland ML, Yee S, Yaylaoglu M, Hussain S, Cosino E, Quinones G, Modrusan Z, Seshagiri S, Torres E, Chopra VS, Haley B, Zhang Z, Blackwood EM, Singh M, Junttila M, Stephan JP, Liu J, Pau G, Fearon ER, Jiang Z, Firestein R
Genes & development 2014 May 15;28(10):1068-84
Genes & development 2014 May 15;28(10):1068-84
Rearrangements within human spliceosomes captured after exon ligation.
Ilagan JO, Chalkley RJ, Burlingame AL, Jurica MS
RNA (New York, N.Y.) 2013 Mar;19(3):400-12
RNA (New York, N.Y.) 2013 Mar;19(3):400-12
Breaking up the C complex spliceosome shows stable association of proteins with the lariat intron intermediate.
Coltri P, Effenberger K, Chalkley RJ, Burlingame AL, Jurica MS
PloS one 2011 Apr 19;6(4):e19061
PloS one 2011 Apr 19;6(4):e19061
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PRPF8 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PRPF8. This antibody recognizes human, mouse, rat antigen. The PRPF8 antibody has been validated for the following applications: ELISA, WB analysis.
