ABIN108525

antibody from antibodies-online

Targeting: MSTN GDF8

Western blot (Recommended by provider)

Antibody Data

Product number

ABIN108525

Provider

antibodies-online

Product name

anti-Myostatin (MSTN) (AA 267-375) antibody

Antibody type

Polyclonal

Antigen

The antibody was raised in bovine by immunization with the recombinant Human Myostatin The immunization antigen (16.7 kDa) is a protein containing 152 AA of recombinant Human Myostatin. N-terminal His-tag including the spacer 43 AA (highlighted). The AA sequence of the human myostatin part of the fusion protein is corresponding to the UniProtKB/Swiss-Prot entry O14793, AA267-375

Description

Immunoaffinity chromatography on a column with immobilized recombinant Human Myostatin

Reactivity

Human

Host

Bovine

Antigen sequence

MRGSHHHHHHGMASMTGGQQ MGRDLYDDDDKDPS
SRSAVRSRRDFGLDCDEHSTESRCCRYPLTVDFEA
FGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLV
HQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYG
KIPAMVVDRCGCS


Epitope

AA 267-375

Vial size

0.1 mg

Storage

The lyophilized antibody remains stable and fully active until the expiry date when stored at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles and store frozen at -80°C. Reconstituted antibody can be stored at 4°C for a limited period of time; it does not show decline in activity after one week at 4°C.

References

Submitted references

Myostatin, a transforming growth factor-beta superfamily member, is expressed in heart muscle and is upregulated in cardiomyocytes after infarct.

Sharma M, Kambadur R, Matthews KG, Somers WG, Devlin GP, Conaglen JV, Fowke PJ, Bass JJ
Journal of cellular physiology 1999 Jul;180(1):1-9

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Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting.

Gonzalez-Cadavid NF, Taylor WE, Yarasheski K, Sinha-Hikim I, Ma K, Ezzat S, Shen R, Lalani R, Asa S, Mamita M, Nair G, Arver S, Bhasin S
Proceedings of the National Academy of Sciences of the United States of America 1998 Dec 8;95(25):14938-43

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Double muscling in cattle due to mutations in the myostatin gene.

McPherron AC, Lee SJ
Proceedings of the National Academy of Sciences of the United States of America 1997 Nov 11;94(23):12457-61