MSTN

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Jul 2016]

Description

myostatin

Protein family

Disease related genes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted secreted proteins, Protein evidence (Peptideatlas)

Chromosome

2:q32.2 (190055700 - 190062729)

Ensembl ID

ENSG00000138379  (ver. 99.38)

Orthologs

Mouse Mstn: ENSMUSG00000026100

UniProt

O14793

neXtProt

NX_O14793

Human splice variants
Mouse splice variants