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- Antibody Data
- Antigen structure
- References [11]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 15202-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15202-1-AP, RRID:AB_2209890
- Product name
- KAP1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated KAP1 antibody (Cat. #15202-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Smoking-associated upregulation of CBX3 suppresses ARHGAP24 expression to activate Rac1 signaling and promote tumor progression in lung adenocarcinoma.
Phosphorylation of the HP1β hinge region sequesters KAP1 in heterochromatin and promotes the exit from naïve pluripotency.
ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons.
TRIM28 maintains genome imprints and regulates development of porcine SCNT embryos.
TRIM28 Expression on Dendritic Cells Prevents Excessive T Cell Priming by Silencing Endogenous Retrovirus.
TRIM28 functions as the SUMO E3 ligase for PCNA in prevention of transcription induced DNA breaks.
TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb.
ASCIZ/ATMIN is dispensable for ATM signaling in response to replication stress.
TRIM28 knockdown increases sensitivity to etoposide by upregulating E2F1 in non-small cell lung cancer.
TRIM28, a new molecular marker predicting metastasis and survival in early-stage non-small cell lung cancer.
Liver-specific ablation of Krüppel-associated box-associated protein 1 in mice leads to male-predominant hepatosteatosis and development of liver adenoma.
Jin X, Zhang B, Zhang H, Yu H
Oncogene 2021 Nov 16;
Oncogene 2021 Nov 16;
Phosphorylation of the HP1β hinge region sequesters KAP1 in heterochromatin and promotes the exit from naïve pluripotency.
Qin W, Ugur E, Mulholland CB, Bultmann S, Solovei I, Modic M, Smets M, Wierer M, Forné I, Imhof A, Cardoso MC, Leonhardt H
Nucleic acids research 2021 Jul 21;49(13):7406-7423
Nucleic acids research 2021 Jul 21;49(13):7406-7423
ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons.
Ma L, Yu L, Jiang BC, Wang J, Guo X, Huang Y, Ren J, Sun N, Gao DS, Ding H, Lu J, Zhou H, Zou L, Gao Y, Wang L, Sun K, Ming Y, Meng Z, Tao YX, Yan M
The Journal of experimental medicine 2021 Dec 6;218(12)
The Journal of experimental medicine 2021 Dec 6;218(12)
TRIM28 maintains genome imprints and regulates development of porcine SCNT embryos.
Zhai Y, Zhang M, An X, Zhang S, Kong X, Li Q, Yu H, Dai X, Li Z
Reproduction (Cambridge, England) 2021 Apr;161(4):411-424
Reproduction (Cambridge, England) 2021 Apr;161(4):411-424
TRIM28 Expression on Dendritic Cells Prevents Excessive T Cell Priming by Silencing Endogenous Retrovirus.
Chikuma S, Yamanaka S, Nakagawa S, Ueda MT, Hayabuchi H, Tokifuji Y, Kanayama M, Okamura T, Arase H, Yoshimura A
Journal of immunology (Baltimore, Md. : 1950) 2021 Apr 1;206(7):1528-1539
Journal of immunology (Baltimore, Md. : 1950) 2021 Apr 1;206(7):1528-1539
TRIM28 functions as the SUMO E3 ligase for PCNA in prevention of transcription induced DNA breaks.
Li M, Xu X, Chang CW, Liu Y
Proceedings of the National Academy of Sciences of the United States of America 2020 Sep 22;117(38):23588-23596
Proceedings of the National Academy of Sciences of the United States of America 2020 Sep 22;117(38):23588-23596
TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb.
Ma X, Yang T, Luo Y, Wu L, Jiang Y, Song Z, Pan T, Liu B, Liu G, Liu J, Yu F, He Z, Zhang W, Yang J, Liang L, Guan Y, Zhang X, Li L, Cai W, Tang X, Gao S, Deng K, Zhang H
eLife 2019 Jan 17;8
eLife 2019 Jan 17;8
ASCIZ/ATMIN is dispensable for ATM signaling in response to replication stress.
Liu R, King A, Hoch NC, Chang C, Kelly GL, Deans AJ, Heierhorst J
DNA repair 2017 Sep;57:29-34
DNA repair 2017 Sep;57:29-34
TRIM28 knockdown increases sensitivity to etoposide by upregulating E2F1 in non-small cell lung cancer.
Liu L, Xiao L, Liang X, Chen L, Cheng L, Zhang L, Wu X, Xu Q, Ma C
Oncology reports 2017 Jun;37(6):3597-3605
Oncology reports 2017 Jun;37(6):3597-3605
TRIM28, a new molecular marker predicting metastasis and survival in early-stage non-small cell lung cancer.
Liu L, Zhao E, Li C, Huang L, Xiao L, Cheng L, Huang X, Song Y, Xu D
Cancer epidemiology 2013 Feb;37(1):71-8
Cancer epidemiology 2013 Feb;37(1):71-8
Liver-specific ablation of Krüppel-associated box-associated protein 1 in mice leads to male-predominant hepatosteatosis and development of liver adenoma.
Bojkowska K, Aloisio F, Cassano M, Kapopoulou A, Santoni de Sio F, Zangger N, Offner S, Cartoni C, Thomas C, Quenneville S, Johnsson K, Trono D
Hepatology (Baltimore, Md.) 2012 Oct;56(4):1279-90
Hepatology (Baltimore, Md.) 2012 Oct;56(4):1279-90
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 15202-1-AP(KAP1 antibody) at dilution of 1:3000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using TRIM28 antibody 15202-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 15202-1-AP(KAP1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 15202-1-AP(KAP1 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
