55133-1-AP

antibody from Proteintech Group

Targeting: S1PR1 CD363, D1S3362, edg-1, EDG1

Provider product page for 55133-1-AP

Western blot

ELISA

Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [36]
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Validations
Western blot [1]

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Product number: 55133-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#55133-1-AP, RRID:AB_10793721
Product name: S1PR1/EDG1 antibody
Antibody type: Polyclonal
Description: KD/KO validated S1PR1/EDG1 antibody (Cat. #55133-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IP, WB, ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

S1PR1 protein structure - 55133-1-AP shown in red.

Submitted references Assessment of the Effects of Sphingosine Kinase 1/Sphingosine-1-Phosphate on Microangiogenesis at Rat Myofascial Trigger Points Using Contrast-Enhanced Ultrasonography.

Fang X, Yin Y, Lun H, Liu Y, Zhu S
Journal of pain research 2024;17:609-621

Pharmacodynamics and mechanism of Erigeron breviscapus granules in the treatment of ischemic stroke in mice by regulating sphingolipid metabolism based on metabolomics.

Liu C, Liu K, Tao X, Li W, Zhao S, Dai Q, Yao H, Mu F, Chen S, Li J, Dong T, Duan J, Wei P, Gao F, Xi M
Journal of pharmaceutical and biomedical analysis 2024 May 15;242:116058

SPHK1/S1P/S1PR pathway promotes the progression of peritoneal fibrosis by mesothelial-mesenchymal transition.

Zhao T, Ding T, Sun Z, Shao X, Li S, Lu H, Yuan JH, Guo Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23417

Calorie restriction mimetic, resveratrol, attenuates hepatic ischemia and reperfusion injury through enhancing efferocytosis of macrophages via AMPK/STAT3/S1PR1 pathway.

Yao X, Liu Y, Mao M, Yang L, Zhan Q, Xiao J
The Journal of nutritional biochemistry 2024 Apr;126:109587

The coumarin component isofraxidin targets the G-protein-coupled receptor S1PR1 to modulate IL-17 signaling and alleviate ulcerative colitis.

Huang Y, Chen X, Liu X, Lin C, Wang Y
International immunopharmacology 2024 Apr 20;131:111814

Proximal tubular MBD2 promotes autophagy to drive the progression of AKI caused by vancomycin via regulation of miR-597-5p/S1PR1 axis.

Guo Y, Wu D, Li X, Wang J, Li H, Li Y, Luo D, Yi F, Zhang D
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Apr 15;38(7):e23562

Emilin2 fosters vascular stability by promoting pericyte recruitment.

Fejza A, Camicia L, Carobolante G, Poletto E, Paulitti A, Schinello G, Di Siena E, Cannizzaro R, Iozzo RV, Baldassarre G, Andreuzzi E, Spessotto P, Mongiat M
Matrix biology : journal of the International Society for Matrix Biology 2023 Sep;122:18-32

Cancer/testis antigen CAGE mediates osimertinib resistance in non-small cell lung cancer cells and predicts poor prognosis in patients with pulmonary adenocarcinoma.

Yeon M, Lee H, Yeo J, Jeong MS, Jung HS, Lee H, Shim K, Jo H, Jeon D, Koh J, Jeoung D
Scientific reports 2023 Sep 21;13(1):15748

Estrogen increases the expression of BKCa and impairs the contraction of colon smooth muscle via upregulation of sphingosine kinase 1.

Wang Y, Jiang Y, Jiang L, Xiong W, Wang Y, Gao X, Chen Q, Lin L, Yu T, Tang Y
Journal of cellular physiology 2023 Oct;238(10):2390-2406

TiO(2) nanoparticles promote tumor metastasis by eliciting pro-metastatic extracellular vesicles.

Mu X, Hu K, Wei A, Bai J, Feng L, Jiang J
Journal of nanobiotechnology 2023 Oct 27;21(1):392

S1PR1 serves as a viable drug target against pulmonary fibrosis by increasing the integrity of the endothelial barrier of the lung.

Hao M, Fu R, Tai J, Tian Z, Yuan X, Chen Y, Wang M, Jiang H, Ji M, Lai F, Xue N, Bai L, Zhu Y, Lv X, Chen X, Jin J
Acta pharmaceutica Sinica. B 2023 Mar;13(3):1110-1127

A novel co-target of ACY1 governing plasma membrane translocation of SphK1 contributes to inflammatory and neuropathic pain.

Liu B, Wu W, Cui L, Zheng X, Li N, Zhang X, Duan G
iScience 2023 Jun 16;26(6):106989

Isorhamnetin attenuates the proliferation, invasion, migration and fibrosis of keloid fibroblasts by targeting S1PR1.

Pu X, Cao X, Liu H, Huang W, Zhang L, Jiang T
Experimental and therapeutic medicine 2023 Jul;26(1):310

Gastrodin synergistically increases migration of interleukin-13 receptor α2 chimeric antigen receptor T cell to the brain against glioblastoma multiforme: A preclinical study.

Huang S, Bai Y, An Z, Xu C, Zhang C, Wang F, Zhong C, Zhong X
Phytotherapy research : PTR 2023 Dec;37(12):5947-5957

A comprehensive multiomics approach reveals that high levels of sphingolipids in cardiac cachexia adipose tissue are associated with inflammatory and fibrotic changes.

Qu Y, Wang Y, Wu T, Liu X, Wang H, Ma D
Lipids in health and disease 2023 Dec 1;22(1):211

Sphingosine 1-phosphate receptor 1 regulates blood-brain barrier permeability in epileptic mice.

Yang LX, Yao YY, Yang JR, Cheng HL, Zhu XJ, Zhang ZJ
Neural regeneration research 2023 Aug;18(8):1763-1769

Fingolimod protects against neurovascular unit injury in a rat model of focal cerebral ischemia/reperfusion injury.

Zhu XY, Ma TT, Li Y, Zhang MQ, Zhao L, Liang J, Min LQ
Neural regeneration research 2023 Apr;18(4):869-874

Dexmedetomidine alleviates oxidative stress and mitochondrial dysfunction in diabetic peripheral neuropathy via the microRNA-34a/SIRT2/S1PR1 axis.

Lin Y, Wei Y, Wei Y, Yu H, Zhang W, Li C, He Y, Yao G, Zhang Y
International immunopharmacology 2023 Apr;117:109910

Global sphingosine-1-phosphate receptor 2 deficiency attenuates neuroinflammation and ischemic-reperfusion injury after neonatal stroke.

Fukuzaki Y, Faustino J, Lecuyer M, Rayasam A, Vexler ZS
iScience 2023 Apr 21;26(4):106340

Geniposide alleviates VEGF-induced angiogenesis by inhibiting VEGFR2/PKC/ERK1/2-mediated SphK1 translocation.

Wang Y, Wu H, Gui BJ, Liu J, Rong GX, Deng R, Bu YH, Zhang H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154068

Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis.

Janneh AH, Kassir MF, Atilgan FC, Lee HG, Sheridan M, Oleinik N, Szulc Z, Voelkel-Johnson C, Nguyen H, Li H, Peterson YK, Marangoni E, Saatci O, Sahin O, Lilly M, Atkinson C, Tomlinson S, Mehrotra S, Ogretmen B
Cell reports 2022 Dec 6;41(10):111742

Potential of a sphingosine 1-phosphate receptor antagonist and sphingosine kinase inhibitors as targets for multiple myeloma treatment.

Tanaka Y, Okabe S, Ohyashiki K, Gotoh A
Oncology letters 2022 Apr;23(4):111

The CAGE-MiR-181b-5p-S1PR1 Axis Regulates Anticancer Drug Resistance and Autophagy in Gastric Cancer Cells.

Yeon M, Kim Y, Pathak D, Kwon E, Kim DY, Jeong MS, Jung HS, Jeoung D
Frontiers in cell and developmental biology 2021;9:666387

Inhibition of Sphingosine-1-Phosphate Receptor 2 Prevents Thoracic Aortic Dissection and Rupture.

Pan G, Liao M, Dai Y, Li Y, Yan X, Mai W, Liu J, Liao Y, Qiu Z, Zhou Z
Frontiers in cardiovascular medicine 2021;8:748486

Interference with the expression of S1PR1 or STAT3 attenuates valvular damage due to rheumatic heart disease.

Xian S, Chen A, Wu Y, Wen H, Lu C, Huang F, Zeng Z
International journal of molecular medicine 2021 Sep;48(3)

Inhibition of sphingosine 1-phosphate (S1P) receptor 1/2/3 ameliorates biological dysfunction in rheumatoid arthritis fibroblast-like synoviocyte MH7A cells through Gαi/Gαs rebalancing.

Wang M, Wu H, Wang R, Dai X, Deng R, Wang Y, Bu Y, Sun M, Zhang H
Clinical and experimental pharmacology & physiology 2021 Aug;48(8):1080-1089

Geniposide downregulates the VEGF/SphK1/S1P pathway and alleviates angiogenesis in rheumatoid arthritis in vivo and in vitro.

Wang Y, Wu H, Deng R, Dai XJ, Bu YH, Sun MH, Zhang H, Wang MD, Wang RH
Phytotherapy research : PTR 2021 Aug;35(8):4347-4362

Bone marrow mesenchymal stem cells-derived exosomes reduce Aβ deposition and improve cognitive function recovery in mice with Alzheimer's disease by activating sphingosine kinase/sphingosine-1-phosphate signaling pathway.

Wang X, Yang G
Cell biology international 2021 Apr;45(4):775-784

Coix Seed Oil Exerts an Anti-Triple-Negative Breast Cancer Effect by Disrupting miR-205/S1PR1 Axis.

Fang T, Jiang YX, Chen L, Huang L, Tian XH, Zhou YD, Nagle DG, Zhang DD
Frontiers in pharmacology 2020;11:529962

Combination of sphingosine-1-phosphate receptor 1 (S1PR1) agonist and antiviral drug: a potential therapy against pathogenic influenza virus.

Zhao J, Zhu M, Jiang H, Shen S, Su X, Shi Y
Scientific reports 2019 Mar 27;9(1):5272

S1P promotes inflammation-induced tube formation by HLECs via the S1PR1/NF-κB pathway.

Zheng Z, Zeng YZ, Ren K, Zhu X, Tan Y, Li Y, Li Q, Yi GH
International immunopharmacology 2019 Jan;66:224-235

Hepatocyte-Derived Lipotoxic Extracellular Vesicle Sphingosine 1-Phosphate Induces Macrophage Chemotaxis.

Liao CY, Song MJ, Gao Y, Mauer AS, Revzin A, Malhi H
Frontiers in immunology 2018;9:2980

Integrated Metabolomics and Network Pharmacology Approach to Explain Possible Action Mechanisms of Xin-Sheng-Hua Granule for Treating Anemia.

Pang HQ, Yue SJ, Tang YP, Chen YY, Tan YJ, Cao YJ, Shi XQ, Zhou GS, Kang A, Huang SL, Shi YJ, Sun J, Tang ZS, Duan JA
Frontiers in pharmacology 2018;9:165

Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2.

Matsushima-Nishiwaki R, Yamada N, Fukuchi K, Kozawa O
PloS one 2018;13(12):e0209050

Sphingosine-1-phosphate mediates AKT/ERK maintenance of dental pulp homoeostasis.

Pan HY, Yang H, Shao MY, Xu J, Zhang P, Cheng R, Hu T
International endodontic journal 2015 May;48(5):460-8

H9N2 avian influenza infection altered expression pattern of sphiogosine-1-phosphate receptor 1 in BALB/c mice.

Tong S, Tian J, Wang H, Huang Z, Yu M, Sun L, Liu R, Liao M, Ning Z
Virology journal 2013 Sep 30;10:296

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The S1PR1 /EDG1 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human S1PR1 /EDG1. This antibody recognizes human, mouse antigen. The S1PR1 /EDG1 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 55133-1-AP.pdf

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