S1PR1

The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Description

sphingosine-1-phosphate receptor 1

Protein family

Cancer-related genes, CD markers, FDA approved drug targets, G-protein coupled receptors, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted membrane proteins, Protein evidence (Peptideatlas), Transporters

Chromosome

1:p21.2 (101236865 - 101243713)

Ensembl ID

ENSG00000170989  (ver. 99.38)

Orthologs

Mouse S1pr1: ENSMUSG00000045092

UniProt

P21453

neXtProt

NX_P21453

Human splice variants
Mouse splice variants