S1PR1

The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Description

Sphingosine-1-phosphate receptor 1

Tissue specificity

Low tissue specificity

Subcell location

Vesicles

Predicted location

Membrane

Protein family

Cancer-related genes
CD markers
FDA approved drug targets
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters

Chromosome

1:p21.2 (101236865 - 101243713)

Ensembl ID

ENSG00000170989  (ver. 103.38)

Orthologs

Mouse S1pr1: ENSMUSG00000045092

UniProt

P21453

neXtProt

NX_P21453

Human splice variants
Mouse splice variants