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- Antibody Data
- Antigen structure
- References [17]
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- Product number
- 10381-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10381-1-AP, RRID:AB_2211979
- Product name
- TTK antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TTK antibody (Cat. #10381-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Deubiquitinase USP8 regulates the spindle assembly checkpoint in oocytes.
Targeting the SIN1 mediated TTK/LDHA-H3K18la-GLUT3 axis disrupts metabolic-epigenetic crosstalk and suppresses progression in hyperglycolytic breast cancer.
TTK promotes mitophagy by regulating ULK1 phosphorylation and pre-mRNA splicing to inhibit mitochondrial apoptosis in bladder cancer.
A Microtubule-Associated Protein Functions in Preventing Oocytes from Evading the Spindle Assembly Checkpoint.
Cyclin B2 facilitates glycolysis and tumor progression in pancreatic ductal adenocarcinoma by promoting histone lactylation.
LncRNA938/ TAF9/TTK axis promotes EMT and serves as a therapeutic target in hepatoblastoma.
Advanced machine learning unveils CD8 + T cell genetic markers enhancing prognosis and immunotherapy efficacy in breast cancer.
PP6 regulation of Aurora A-TPX2 limits NDC80 phosphorylation and mitotic spindle size.
Targeting of RRM2 suppresses DNA damage response and activates apoptosis in atypical teratoid rhabdoid tumor.
GRP75-driven, cell-cycle-dependent macropinocytosis of Tat/pDNA-Ca(2+) nanoparticles underlies distinct gene therapy effect in ovarian cancer.
TTK Protein Kinase promotes temozolomide resistance through inducing autophagy in glioblastoma.
Identification and Validation of Hub Genes Associated with Bladder Cancer by Integrated Bioinformatics and Experimental Assays.
Characteristic Analysis of Featured Genes Associated With Stemness Indices in Colorectal Cancer.
Bioinformatics analysis and experimental validation of TTK as a biomarker for prognosis in non-small cell lung cancer.
Development and validation of a five-gene model to predict postoperative brain metastasis in operable lung adenocarcinoma.
Silencing TTK expression inhibits the proliferation and progression of prostate cancer.
Oxidative Stress Delays Prometaphase/Metaphase of the First Cleavage in Mouse Zygotes via the MAD2L1-Mediated Spindle Assembly Checkpoint.
Zhou 周长银 C, Zhang 张雪 X, Xu 许根露 G, Wang 王慧 H, Ran 冉宇婷 Y, Li 李昂 A, Sun 孙青原 QY, Ou 欧湘红 XH
Science advances 2026 Mar 13;12(11):eaeb2345
Science advances 2026 Mar 13;12(11):eaeb2345
Targeting the SIN1 mediated TTK/LDHA-H3K18la-GLUT3 axis disrupts metabolic-epigenetic crosstalk and suppresses progression in hyperglycolytic breast cancer.
Zhao Z, Jia W, Li Z, Shi S, Zhou J, Ning C, Yu Z, Liu X, Cao X, Zheng H, Wang X, Wang X, Yu Y
Cancer letters 2026 Apr 28;644:218328
Cancer letters 2026 Apr 28;644:218328
TTK promotes mitophagy by regulating ULK1 phosphorylation and pre-mRNA splicing to inhibit mitochondrial apoptosis in bladder cancer.
Chen K, Chen J, Cong Y, He Q, Liu C, Chen J, Li H, Ju Y, Chen L, Song Y, Xing Y
Cell death and differentiation 2025 Sep;32(9):1691-1706
Cell death and differentiation 2025 Sep;32(9):1691-1706
A Microtubule-Associated Protein Functions in Preventing Oocytes from Evading the Spindle Assembly Checkpoint.
Zhou C, Zhang X, Xu G, Ran Y, Wang H, Xie X, Li A, Li F, Li X, Ding J, Zhang M, Sun QY, Ou XH
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(7):e2413097
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(7):e2413097
Cyclin B2 facilitates glycolysis and tumor progression in pancreatic ductal adenocarcinoma by promoting histone lactylation.
Ma B, Li X, Ma Z, Yin Z, Gao L, Wang Y, Shi J, Liu X, Chen H
BMC cancer 2025 Dec 7;26(1):63
BMC cancer 2025 Dec 7;26(1):63
LncRNA938/ TAF9/TTK axis promotes EMT and serves as a therapeutic target in hepatoblastoma.
Jin C, Dong B, Xie Y, Chen X, Wu S, Du F, Dong Q, Zhu C
Journal of translational medicine 2025 Aug 21;23(1):946
Journal of translational medicine 2025 Aug 21;23(1):946
Advanced machine learning unveils CD8 + T cell genetic markers enhancing prognosis and immunotherapy efficacy in breast cancer.
Ma H, Shi L, Zheng J, Zeng L, Chen Y, Zhang S, Tang S, Qu Z, Xiong X, Zheng X, Yin Q
BMC cancer 2024 Oct 1;24(1):1222
BMC cancer 2024 Oct 1;24(1):1222
PP6 regulation of Aurora A-TPX2 limits NDC80 phosphorylation and mitotic spindle size.
Sobajima T, Kowalczyk KM, Skylakakis S, Hayward D, Fulcher LJ, Neary C, Batley C, Kurlekar S, Roberts E, Gruneberg U, Barr FA
The Journal of cell biology 2023 May 1;222(5)
The Journal of cell biology 2023 May 1;222(5)
Targeting of RRM2 suppresses DNA damage response and activates apoptosis in atypical teratoid rhabdoid tumor.
Giang LH, Wu KS, Lee WC, Chu SS, Do AD, Changou CA, Tran HM, Hsieh TH, Chen HH, Hsieh CL, Sung SY, Yu AL, Yen Y, Wong TT, Chang CC
Journal of experimental & clinical cancer research : CR 2023 Dec 20;42(1):346
Journal of experimental & clinical cancer research : CR 2023 Dec 20;42(1):346
GRP75-driven, cell-cycle-dependent macropinocytosis of Tat/pDNA-Ca(2+) nanoparticles underlies distinct gene therapy effect in ovarian cancer.
Su L, Sun Z, Qi F, Su H, Qian L, Li J, Zuo L, Huang J, Yu Z, Li J, Chen Z, Zhang S
Journal of nanobiotechnology 2022 Jul 20;20(1):340
Journal of nanobiotechnology 2022 Jul 20;20(1):340
TTK Protein Kinase promotes temozolomide resistance through inducing autophagy in glioblastoma.
Yu J, Gao G, Wei X, Wang Y
BMC cancer 2022 Jul 18;22(1):786
BMC cancer 2022 Jul 18;22(1):786
Identification and Validation of Hub Genes Associated with Bladder Cancer by Integrated Bioinformatics and Experimental Assays.
Chen K, Xing J, Yu W, Xia Y, Zhang Y, Cheng F, Rao T
Frontiers in oncology 2021;11:782981
Frontiers in oncology 2021;11:782981
Characteristic Analysis of Featured Genes Associated With Stemness Indices in Colorectal Cancer.
Lu Y, Zhou X, Liu Z, Wang W, Li F, Fu W
Frontiers in molecular biosciences 2020;7:563922
Frontiers in molecular biosciences 2020;7:563922
Bioinformatics analysis and experimental validation of TTK as a biomarker for prognosis in non-small cell lung cancer.
Chen J, Wu R, Xuan Y, Jiang M, Zeng Y
Bioscience reports 2020 Oct 30;40(10)
Bioscience reports 2020 Oct 30;40(10)
Development and validation of a five-gene model to predict postoperative brain metastasis in operable lung adenocarcinoma.
Fu F, Zhang Y, Gao Z, Zhao Y, Wen Z, Han H, Li Y, Chen H
International journal of cancer 2020 Jul 15;147(2):584-592
International journal of cancer 2020 Jul 15;147(2):584-592
Silencing TTK expression inhibits the proliferation and progression of prostate cancer.
Chen S, Wang J, Wang L, Peng H, Xiao L, Li C, Lin D, Yang K
Experimental cell research 2019 Dec 1;385(1):111669
Experimental cell research 2019 Dec 1;385(1):111669
Oxidative Stress Delays Prometaphase/Metaphase of the First Cleavage in Mouse Zygotes via the MAD2L1-Mediated Spindle Assembly Checkpoint.
Wu Q, Li Z, Huang Y, Qian D, Chen M, Xiao W, Wang B
Oxidative medicine and cellular longevity 2017;2017:2103190
Oxidative medicine and cellular longevity 2017;2017:2103190
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