17353-1-AP

antibody from Proteintech Group

Targeting: TIMP2 CSC-21K

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

17353-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#17353-1-AP, RRID:AB_2287495

Product name

TIMP-2 antibody

Antibody type

Polyclonal

Description

TIMP-2 antibody (Cat. #17353-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Suppression of Migration and Invasion by 4-Carbomethoxyl-10-Epigyrosanoldie E from the Cultured Soft Coral Sinularia sandensis through the MAPKs Pathway on Oral Cancer Cells.

Fang RY, Liu YW, Goan YG, Lin JJ, Su JH, Wu WT, Wu YJ
Advances in pharmacological and pharmaceutical sciences 2024;2024:6695837

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Ulipristal (UPA) effects on rat ovaries: Unraveling follicle dynamics, ovulation inhibition, and safety implications for prolonged use.

Hirano M, Wada-Hiraike O, Fukui M, Shibata S, Uehara M, Nagumo A, Urata Y, Sone K, Harada M, Koga K, Osuga Y
Reproductive toxicology (Elmsford, N.Y.) 2024 Apr;125:108571

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PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis.

Lai W, Yu L, Deng Y
Communications biology 2024 Apr 9;7(1):429

---

Jin-Gui-Shen-Qi Wan alleviates fibrosis in mouse diabetic nephropathy via MHC class II.

Liang D, Liu L, Qi Y, Nan F, Huang J, Tang S, Tang J, Chen N
Journal of ethnopharmacology 2024 Apr 24;324:117745

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α1,3-fucosylation of MEST promotes invasion potential of cytotrophoblast cells by activating translation initiation.

Wang H, Cui X, Wang L, Fan N, Yu M, Qin H, Liu S, Yan Q
Cell death & disease 2023 Oct 6;14(10):651

---

PTEN Inhibitor Treatment Lowers Muscle Plasma Membrane Damage and Enhances Muscle ECM Homeostasis after High-Intensity Eccentric Exercise in Mice.

Wu B, Shi L, Wu Y
International journal of molecular sciences 2023 Jun 9;24(12)

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TDG suppresses the migration and invasion of human colon cancer cells via the DNMT3A/TIMP2 axis.

Miao J, Zhao C, Tang K, Xiong X, Wu F, Xue W, Duan B, Zhang H, Jing X, Li W, Sun Y, Hou N, Huang C
International journal of biological sciences 2022;18(6):2527-2539

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LASS2 impairs proliferation of glioma stem cells and migration and invasion of glioma cells mainly via inhibition of EMT and apoptosis promotion.

Zhao WJ, Fan YP, Ou GY, Qiao XY
Journal of Cancer 2022;13(7):2281-2292

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YY1/ITGA3 pathway may affect trophoblastic cells migration and invasion ability.

Wang Y, Yang D, Zhu R, Dai F, Yuan M, Zhang L, Zheng Y, Liu S, Yang X, Cheng Y
Journal of reproductive immunology 2022 Sep;153:103666

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Oncogenic GBX2 promotes the malignant behaviors of bladder cancer cells by binding to the ITGA5 promoter and activating its transcription.

Xiong Y, Song X, Kudusi, Zu X, Chen M, He W, Qi L
Functional & integrative genomics 2022 Oct;22(5):937-950

---

Integration of exosomal miR-106a and mesothelial cells facilitates gastric cancer peritoneal dissemination.

Zhu M, Zhang N, Ma J, He S
Cellular signalling 2022 Mar;91:110230

---

Cystathionine γ-lyase mediates cell proliferation, migration, and invasion of nasopharyngeal carcinoma.

Zhang Q, Gao Y, Zhang Y, Jing M, Wang D, Wang Y, Khattak S, Qi H, Cai C, Zhang J, Ngowi EE, Khan NH, Li T, Ji A, Jiang Q, Ji X, Li Y, Wu D
Oncogene 2022 Dec;41(49):5238-5252

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Nav1.6 promotes the progression of human follicular thyroid carcinoma cells via JAK-STAT signaling pathway.

Li H, Liu J, Fan N, Wang H, Thomas AM, Yan Q, Li S, Qin H
Pathology, research and practice 2022 Aug;236:153984

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Staphylococcus aureus on the effect of expression of MMPs/TIMPs and uPA system in bovine mammary fibroblasts.

Miao Z, Ding Y, Bi Y, Chen M, Cao X, Wang F
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2021 Jun;54(3):411-419

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Apatinib Inhibits the Invasion and Metastasis of Liver Cancer Cells by Downregulating MMP-Related Proteins via Regulation of the NF-κB Signaling Pathway.

He X, Huang Z, Liu P, Li Q, Wang M, Qiu M, Xiong Z, Yang S
BioMed research international 2020;2020:3126182

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Biological and Proteomic Characteristics of an Immortalized Human Pancreatic Stellate Cell Line.

Sun L, Qu L, Brigstock DR, Li H, Li Y, Gao R
International journal of medical sciences 2020;17(1):137-144

---

Circular RNA circ_0111277 attenuates human trophoblast cell invasion and migration by regulating miR-494/HTRA1/Notch-1 signal pathway in pre-eclampsia.

Ou Y, Zhu L, Wei X, Bai S, Chen M, Chen H, Zhang J
Cell death & disease 2020 Jun 25;11(6):479

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Exogenous hydrogen sulfide inhibits apoptosis by regulating endoplasmic reticulum stress-autophagy axis and improves myocardial reconstruction after acute myocardial infarction.

Li Y, Liu M, Yi J, Song X, Zheng X, Liu D, Wang S, Chu C, Yang J
Acta biochimica et biophysica Sinica 2020 Dec 29;52(12):1325-1336

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Transcriptome sequencing reveals fibrotic associated-genes involved in bovine mammary fibroblasts with Staphylococcus aureus.

Miao Z, Ding Y, Zhao N, Chen X, Cheng H, Wang J, Liu Y, Wang F
The international journal of biochemistry & cell biology 2020 Apr;121:105696

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Effects of simvastatin on matrix metalloproteinase regulation in IL-1β-induced SW1353 cells.

Cecen B, Keles D, Oktay G, Kozaci LD
Chemico-biological interactions 2019 Sep 1;310:108730

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Aristolochic Acid Affects Upper Tract Urothelial Cancer Behavior through the MAPK Pathway.

Chen IH, Luo HL, Su YL, Huang CC, Chiang PH, Yu CC, Lee NL, Lin JJ, Sung MT
Molecules (Basel, Switzerland) 2019 Oct 15;24(20)

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Lanthanum Chloride Impairs the Blood-Brain Barrier Integrity by Reduction of Junctional Proteins and Upregulation of MMP-9 in Rats.

Wu J, Yang J, Lu X, Jin C, Wu S, Zhang L, Hu X, Ma H, Cai Y
Biological trace element research 2019 Feb;187(2):482-491

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Herba Artemisiae Capillaris Extract Prevents the Development of Streptozotocin-Induced Diabetic Nephropathy of Rat.

Geng J, Yu X, Liu C, Sun C, Guo M, Li Z, Jin Y, Zou Y, Yu J
Evidence-based complementary and alternative medicine : eCAM 2018;2018:5180165

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Rab7 empowers renal tubular epithelial cells with autophagy-mediated protection against albumin-induced injury.

Liu L, Li Y, Wang Z, Ding F, Cheng Z, Xu Q, Cai Y, Limbu MH, Yang Y, Liu B, Chen P
Experimental cell research 2018 Sep 15;370(2):198-207

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Molecularly targeted anti-cancer drugs inhibit the invasion and metastasis of hepatocellular carcinoma by regulating the expression of MMP and TIMP gene families.

He XX, Shi LL, Qiu MJ, Li QT, Wang MM, Xiong ZF, Yang SL
Biochemical and biophysical research communications 2018 Oct 12;504(4):878-884

---

MicroRNA-124a inhibits cell proliferation and migration in liver cancer by regulating interleukin-11.

Yu L, Wang S, Lin X, Lu Y, Gu P
Molecular medicine reports 2018 Mar;17(3):3972-3978

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Stachydrine ameliorates carbon tetrachloride-induced hepatic fibrosis by inhibiting inflammation, oxidative stress and regulating MMPs/TIMPs system in rats.

Zhang J, Yang A, Wu Y, Guan W, Xiong B, Peng X, Wei X, Chen C, Liu Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:1586-1594

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Hepatoprotective effects of ethyl pyruvate against CCl4-induced hepatic fibrosis via inhibition of TLR4/NF-κB signaling and up-regulation of MMPs/TIMPs ratio.

Zhang M, Hu X, Li S, Lu C, Li J, Zong Y, Qi W, Yang H
Clinics and research in hepatology and gastroenterology 2018 Feb;42(1):72-81

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Cryptotanshinone inhibits the growth and invasion of colon cancer by suppressing inflammation and tumor angiogenesis through modulating MMP/TIMP system, PI3K/Akt/mTOR signaling and HIF-1α nuclear translocation.

Zhang L, Chen C, Duanmu J, Wu Y, Tao J, Yang A, Yin X, Xiong B, Gu J, Li C, Liu Z
International immunopharmacology 2018 Dec;65:429-437

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RAB37 Hypermethylation Regulates Metastasis and Resistance to Docetaxel-Based Induction Chemotherapy in Nasopharyngeal Carcinoma.

Li Y, Yang X, Du X, Lei Y, He Q, Hong X, Tang X, Wen X, Zhang P, Sun Y, Zhang J, Wang Y, Ma J, Liu N
Clinical cancer research : an official journal of the American Association for Cancer Research 2018 Dec 15;24(24):6495-6508

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Evaluation of the Inhibitory Effects of Genipin on the Fluoxetine-Induced Invasive and Metastatic Model in Human HepG2 Cells.

Tian YS, Chen KC, Zulkefli ND, Maner RS, Hsieh CL
Molecules (Basel, Switzerland) 2018 Dec 14;23(12)

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Exosomal miR-93 promotes proliferation and invasion in hepatocellular carcinoma by directly inhibiting TIMP2/TP53INP1/CDKN1A.

Xue X, Wang X, Zhao Y, Hu R, Qin L
Biochemical and biophysical research communications 2018 Aug 25;502(4):515-521

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Flaccidoxide-13-Acetate Extracted from the Soft Coral Cladiella kashmani Reduces Human Bladder Cancer Cell Migration and Invasion through Reducing Activation of the FAK/PI3K/AKT/mTOR Signaling Pathway.

Neoh CA, Wu WT, Dai GF, Su JH, Liu CI, Su TR, Wu YJ
Molecules (Basel, Switzerland) 2017 Dec 27;23(1)

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Sinulariolide Suppresses Cell Migration and Invasion by Inhibiting Matrix Metalloproteinase-2/-9 and Urokinase through the PI3K/AKT/mTOR Signaling Pathway in Human Bladder Cancer Cells.

Cheng TC, Din ZH, Su JH, Wu YJ, Liu CI
Marine drugs 2017 Aug 2;15(8)

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MicroRNA-106a functions as an oncogene in human gastric cancer and contributes to proliferation and metastasis in vitro and in vivo.

Zhu M, Zhang N, He S, Yan R, Zhang J
Clinical & experimental metastasis 2016 Jun;33(5):509-19

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Induction of forkhead box M1 (FoxM1) by EGF through ERK signaling pathway promotes trophoblast cell invasion.

Xie Y, Cui D, Sui L, Xu Y, Zhang N, Ma Y, Li Y, Kong Y
Cell and tissue research 2015 Nov;362(2):421-30

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11-epi-Sinulariolide acetate reduces cell migration and invasion of human hepatocellular carcinoma by reducing the activation of ERK1/2, p38MAPK and FAK/PI3K/AKT/mTOR signaling pathways.

Lin JJ, Su JH, Tsai CC, Chen YJ, Liao MH, Wu YJ
Marine drugs 2014 Sep 12;12(9):4783-98

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with 17353-1-AP( TIMP2 Antibody) at dilution of 1:1000

Sample type

cell line

Immunocytochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunofluorescent analysis of HepG2 cells, using TIMP2 antibody 17353-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human placenta using 17353-1-AP(TIMP2 antibody) at dilution of 1:50 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human placenta using 17353-1-AP(TIMP2 antibody) at dilution of 1:50 (under 40x lens)

Sample type

tissue