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- Antibody Data
- Antigen structure
- References [1]
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- Product number
- 635401 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#635401, RRID:AB_2287490
- Product name
- Purified anti-TIMP-2
- Antibody type
- Monoclonal
- Antigen
- Ovalbumin-conjugated synthetic Peptide DSGNDIYGNPI
- Description
- TIMP-2 (Tissue inhibitor of metalloproteinase 2) is a nonglycosylated protein that belongs to the protease inhibitor I35 (TIMP) family. Contains 1 NTR domain, predicted molecular weight 24 kD. The mechanisms of TIMPs inhibit angiogenesis appear to be specific for each member of the TIMP family. TIMP-2 binds to the surface of human endothelial cells through interaction with the integrin α3β1, and abrogates angiogenic factor induced endothelial cell proliferation in vitro and angiogenesis in vivo independent of MMP inhibition. Clone F27P3A4 has been shown to be useful for western blotting, immunohistochemistry and ELISA of human, mouse, rabbit, chicken, zebrafish, and pig TIMP-2.
- Reactivity
- Human, Mouse, Chicken/Avian, Porcine, Rabbit, Zebrafish
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 25 µg
- Concentration
- 0.5 mg/ml
- Storage
- Upon receipt, store undiluted at 4°C.
Submitted references Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion.
Fromigué O, Hamidouche Z, Marie PJ
The Journal of biological chemistry 2008 Nov 7;283(45):30549-56
The Journal of biological chemistry 2008 Nov 7;283(45):30549-56
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- BioLegend (provider)
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- Experimental details
- Western blot analysis of recombinant human TIMP-2 protein using anti-TIMP-2, clone F27P3A4.
- Conjugate
- Unconjugated
