FOSB

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

FosB proto-oncogene, AP-1 transcription factor subunit

Protein family

Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Peptideatlas), Transcription factors

Chromosome

19:q13.32 (45467995 - 45475179)

Ensembl ID

ENSG00000125740  (ver. 99.38)

Orthologs

Mouse Fosb: ENSMUSG00000003545

UniProt

P53539

neXtProt

NX_P53539

Human splice variants
Mouse splice variants