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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [5]
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- Validations
- Flow cytometry [1]
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- Product number
- FAB391P-100 - Provider product page
- Provider
- R&D Systems
- Product name
- Human IGF-I R/IGF1R PE-conjugated Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human IGF-I R in sandwich ELISAs and Western blots. In sandwich ELISAs, less than 0.15% cross-reactivity or interference was observed with recombinant human (rh) IGF-I, rhIGF-II, rhIL-3 R alpha , rhIL-9 R, and rhTGF-beta RII.
- Reactivity
- Human
- Host
- Mouse
- Antigen sequence
P08069- Isotype
- IgG
- Antibody clone number
- 33255
- Vial size
- 100 Tests
- Storage
- Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied.
Submitted references Quantification of IGF-1 Receptor May Be Useful in Diagnosing Polycythemia Vera-Suggestion to Be Added to Be One of the Minor Criterion.
Phenotyping of human melanoma cells reveals a unique composition of receptor targets and a subpopulation co-expressing ErbB4, EPO-R and NGF-R.
Co-targeting the IGF system and HIF-1 inhibits migration and invasion by (triple-negative) breast cancer cells.
Clinical and functional characterization of a patient carrying a compound heterozygous pericentrin mutation and a heterozygous IGF1 receptor mutation.
Insulin-like growth factor I (IGF-I) stimulates proliferation but also increases caspase-3 activity, Annexin-V binding, and DNA-fragmentation in human MG63 osteosarcoma cells: co-activation of pro- and anti-apoptotic pathways by IGF-I.
Wang JC, Shi G, Baptiste S, Yarotska M, Sindhu H, Wong C, Kalavar M, Gotlieb V, Bandarchuk A, Chen H
PloS one 2016;11(11):e0165299
PloS one 2016;11(11):e0165299
Phenotyping of human melanoma cells reveals a unique composition of receptor targets and a subpopulation co-expressing ErbB4, EPO-R and NGF-R.
Mirkina I, Hadzijusufovic E, Krepler C, Mikula M, Mechtcheriakova D, Strommer S, Stella A, Jensen-Jarolim E, Höller C, Wacheck V, Pehamberger H, Valent P
PloS one 2014;9(1):e84417
PloS one 2014;9(1):e84417
Co-targeting the IGF system and HIF-1 inhibits migration and invasion by (triple-negative) breast cancer cells.
Mancini M, Gariboldi MB, Taiana E, Bonzi MC, Craparotta I, Pagin M, Monti E
British journal of cancer 2014 Jun 10;110(12):2865-73
British journal of cancer 2014 Jun 10;110(12):2865-73
Clinical and functional characterization of a patient carrying a compound heterozygous pericentrin mutation and a heterozygous IGF1 receptor mutation.
Müller E, Dunstheimer D, Klammt J, Friebe D, Kiess W, Kratzsch J, Kruis T, Laue S, Pfäffle R, Wallborn T, Heidemann PH
PloS one 2012;7(5):e38220
PloS one 2012;7(5):e38220
Insulin-like growth factor I (IGF-I) stimulates proliferation but also increases caspase-3 activity, Annexin-V binding, and DNA-fragmentation in human MG63 osteosarcoma cells: co-activation of pro- and anti-apoptotic pathways by IGF-I.
Raile K, Hille R, Laue S, Schulz A, Pfeifer G, Horn F, Kiess W
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2003 Nov-Dec;35(11-12):786-93
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 2003 Nov-Dec;35(11-12):786-93
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Supportive validation
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- R&D Systems (provider)
- Main image
- Experimental details
- Detection of IGF-I R in MCF-7 Human Cell Line by Flow Cytometry. MCF-7 human breast cancer cell line was stained with Mouse Anti-Human IGF-I R PE-conjugated Monoclonal Antibody (Catalog # FAB391P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.
