IGF1R

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

Description

insulin like growth factor 1 receptor

Protein family

Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014), RAS pathway related proteins

Chromosome

15:q26.3 (98648971 - 98964530)

Ensembl ID

ENSG00000140443  (ver. 84.38)

Orthologs

Mouse Igf1r: ENSMUSG00000005533

UniProt

P08069

neXtProt

NX_P08069

Human splice variants
Mouse splice variants