Antibody data
- Antibody Data
- Antigen structure
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- Product number
- TAB-078 - Provider product page
- Provider
- Creative Biolabs
- Product name
- Anti-Human IGF1 Receptor Recombinant Antibody (Cixutumumab)
- Antibody type
- Monoclonal
- Description
- Recombinant monoclonal antibody to IGF1 Receptor. Cixutumumab is a monoclonal antibody for the treatment of solid tumors. It is a fully human IgG1 monoclonal antibody directed against the human insulin-like growth factor-1 receptor (IGF-1R) with potential antineoplastic activity. Cixutumumab selectively binds to membrane-bound IGF-1R, thereby preventing the binding of the natural ligand IGF-1 and the subsequent activation of PI3K/AKT signaling pathway. Downregulation of the PI3K/AKT survival pathway may result in the induction of cancer cell apoptosis and may decrease cancer cellular proliferation. IGF-1R, a receptor tyrosine kinase of the insulin receptor superfamily overexpressed by many cancer cell types, stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis; IGF-1R signaling has been implicated in tumorigenesis and metastasis.
- Reactivity
- Human
- Host
- Human
- Storage
- Store at 4¡ãC for up to 3 months. For longer term storage aliquot into small volumes and store at -20¡ãC.
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