TAB-078

antibody from Creative Biolabs

Targeting: IGF1R CD221, IGFIR, IGFR, JTK13, MGC18216

No application information provided.

Antibody Data

Product number

TAB-078

Provider

Creative Biolabs

Product name

Anti-Human IGF1 Receptor Recombinant Antibody (Cixutumumab)

Antibody type

Monoclonal

Description

Recombinant monoclonal antibody to IGF1 Receptor. Cixutumumab is a monoclonal antibody for the treatment of solid tumors. It is a fully human IgG1 monoclonal antibody directed against the human insulin-like growth factor-1 receptor (IGF-1R) with potential antineoplastic activity. Cixutumumab selectively binds to membrane-bound IGF-1R, thereby preventing the binding of the natural ligand IGF-1 and the subsequent activation of PI3K/AKT signaling pathway. Downregulation of the PI3K/AKT survival pathway may result in the induction of cancer cell apoptosis and may decrease cancer cellular proliferation. IGF-1R, a receptor tyrosine kinase of the insulin receptor superfamily overexpressed by many cancer cell types, stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis; IGF-1R signaling has been implicated in tumorigenesis and metastasis.

Reactivity

Human

Storage

Store at 4¡ãC for up to 3 months. For longer term storage aliquot into small volumes and store at -20¡ãC.