Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- BS6441 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- PI3K p110ÎÛ(PIK3CG) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human PI3K p110ÎÛ.
- Description
- Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of p85 and p110 subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85Ï« and p85ÉÇ), each possessing one SH3 and two SH2 domains. Various p110 isoforms have been identified. p110Ï« and p110ÉÇ interact with p85Ï«, and p110Ï« has also been shown to interact with p85ÉÇ in vitro. p110ÎÛ expression is restricted to white blood cells. It has been shown to bind p85Ï« and ÉÇ, but it apparently does not phosphorylate these subunits. p110ÎÛ seems to have the capacity to autophosphorylate. p110 does not interact with the p85 subunits. It has been shown to be activated by Ï« and ÉÇ heterotrimeric G proteins.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- WesternBlot (WB) analysis of PI3 Kinase p110¦Ã (PIK3CG) pAb in extracts from Jurkat and Hela cells.