PIK3CG

Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta), the encoded protein binds a p85 regulatory subunit to form PI3K. This gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2015]

Description

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

Tissue specificity

Group enriched (bone marrow, lymphoid tissue)

Subcell location

Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Cancer-related genes
Enzymes
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

7 (106865278 - 106908980)

Ensembl ID

ENSG00000105851  (ver. 103.38)

Orthologs

Mouse Pik3cg: ENSMUSG00000020573

UniProt

P48736

neXtProt

NX_P48736

Human splice variants
Mouse splice variants

Protein structure