Antibody data
- Antibody Data
- Antigen structure
- References [4]
- Comments [0]
- Validations
- Blocking/Neutralizing [1]
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- Product number
- MAB959-100 - Provider product page
- Provider
- R&D Systems
- Product name
- Mouse Erythropoietin/EPO Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects mouse Erythropoietin/EPO.
- Reactivity
- Mouse
- Host
- Rat
- Conjugate
- Unconjugated
- Antigen sequence
P07321
- Isotype
- IgG
- Antibody clone number
- 148438
- Vial size
- 100 ug
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury.
Stress-associated erythropoiesis initiation is regulated by type 1 conventional dendritic cells.
Transforming growth factor-β superfamily ligand trap ACE-536 corrects anemia by promoting late-stage erythropoiesis.
Innate immune activation during Salmonella infection initiates extramedullary erythropoiesis and splenomegaly.
Billin AN, Honeycutt SE, McDougal AV, Kerr JP, Chen Z, Freudenberg JM, Rajpal DK, Luo G, Kramer HF, Geske RS, Fang F, Yao B, Clark RV, Lepore J, Cobitz A, Miller R, Nosaka K, Hinken AC, Russell AJ
Skeletal muscle 2018 Nov 13;8(1):35
Skeletal muscle 2018 Nov 13;8(1):35
Stress-associated erythropoiesis initiation is regulated by type 1 conventional dendritic cells.
Kim TS, Hanak M, Trampont PC, Braciale TJ
The Journal of clinical investigation 2015 Oct 1;125(10):3965-80
The Journal of clinical investigation 2015 Oct 1;125(10):3965-80
Transforming growth factor-β superfamily ligand trap ACE-536 corrects anemia by promoting late-stage erythropoiesis.
Suragani RN, Cadena SM, Cawley SM, Sako D, Mitchell D, Li R, Davies MV, Alexander MJ, Devine M, Loveday KS, Underwood KW, Grinberg AV, Quisel JD, Chopra R, Pearsall RS, Seehra J, Kumar R
Nature medicine 2014 Apr;20(4):408-14
Nature medicine 2014 Apr;20(4):408-14
Innate immune activation during Salmonella infection initiates extramedullary erythropoiesis and splenomegaly.
Jackson A, Nanton MR, O'Donnell H, Akue AD, McSorley SJ
Journal of immunology (Baltimore, Md. : 1950) 2010 Nov 15;185(10):6198-204
Journal of immunology (Baltimore, Md. : 1950) 2010 Nov 15;185(10):6198-204
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Supportive validation
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- R&D Systems (provider)
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- Experimental details
- Cell Proliferation Induced by Erythropoietin/EPO and Neutralization by Mouse Erythropoietin/EPO Antibody. Recombinant Mouse Erythropoietin/EPO (Catalog # 959-ME) stimulates proliferation in the TF-1 human erythroleukemic cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Mouse Erythropoietin/EPO (40 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Erythropoietin/EPO Monoclonal Antibody (Catalog # MAB959). The ND50 is typically 0.2-0.8 µg/mL.