Explore
Validate
Learn10150-2-AP
antibody from Proteintech Group
Targeting: GNAS
GNAS1, GNASXL, GPSA, NESP, NESP55, SCG6, SgVI
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [21]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 10150-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10150-2-AP, RRID:AB_2111668
- Product name
- GNAS antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated GNAS antibody (Cat. #10150-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Isomeranzin activates Gnas-AMPK signaling to drive white adipose browning and curb obesity in mice.
GNAS/PKA signaling promotes aberrant osteochondral differentiation of Gli1(+) tendon sheath progenitors.
GPR35 prevents drug-induced liver injury via the Gαs-cAMP-PKA axis in macrophages.
Discovery of a functionally selective serotonin receptor (5-HT(1A)R) agonist for the treatment of pain.
Dual Role of NRF2 in Pancreatic Precursor Lesions.
Sympathetic nerve promotes renal fibrosis by activating M2 macrophages through β2-AR-Gsa.
Exosomal mir-126-3p derived from endothelial cells induces ion channel dysfunction by targeting RGS3 signaling in cardiomyocytes: a novel mechanism in Takotsubo cardiomyopathy.
Caloric restriction prevents inheritance of polycystic ovary syndrome through oocyte-mediated DNA methylation reprogramming.
Long Mu Qing Xin mixture improves behavioral performance in spontaneously hypertensive rats (SHR/NCrl) by upregulating catecholamine neurotransmitters in prefrontal cortex and striatum via DRD1/cAMP/PKA-CREB signaling pathway.
PRKDC Induces Chemoresistance in Osteosarcoma by Recruiting GDE2 to Stabilize GNAS and Activate AKT.
GNAS knockout potentiates HDAC3 inhibition through viral mimicry-related interferon responses in lymphoma.
Sex-specific transgenerational effects on murine thyroid gland imposed by ancestral exposure to neonicotinoid thiacloprid.
A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways.
Activation of melanocortin-1 receptor signaling in melanoma cells impairs T cell infiltration to dampen antitumor immunity.
Association of elevated autoantibody to high expression of GNAS in hepatocellular carcinoma.
Gsα deficiency facilitates cardiac remodeling via CREB/ Bmp10-mediated signaling.
GNAS promotes inflammation-related hepatocellular carcinoma progression by promoting STAT3 activation.
A novel GNAS-mutated human induced pluripotent stem cell model for understanding GNAS-mutated tumors.
Ablation of Gsa impairs renal tubule proliferation after injury via CDK2/cyclin E.
Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility.
HDAC2 and TXNL1 distinguish aneuploid from diploid colorectal cancers.
Shi M, Ye Y, Hu L, Yan Y, Jiang S, Wang P, Li F, Ai M, Huang J, Yang L, Huang K, Liang M
EMBO molecular medicine 2026 Jan;18(1):55-90
EMBO molecular medicine 2026 Jan;18(1):55-90
GNAS/PKA signaling promotes aberrant osteochondral differentiation of Gli1(+) tendon sheath progenitors.
Chen L, Peng C, Chai L, Zhang R, Zhu C, Wang H, Cheng Q, Yan Y, Shen C, Zheng H, Yang J, Fan H, Kan C
The EMBO journal 2025 Oct;44(20):5890-5917
The EMBO journal 2025 Oct;44(20):5890-5917
GPR35 prevents drug-induced liver injury via the Gαs-cAMP-PKA axis in macrophages.
Zhao X, Li Y, Yang L, Chen X, Zhang J, Chen T, Wang H, Li F, Cheng C, Wu J, Cong J, Yin W, Li J, Wang X
Cellular and molecular life sciences : CMLS 2025 May 29;82(1):219
Cellular and molecular life sciences : CMLS 2025 May 29;82(1):219
Discovery of a functionally selective serotonin receptor (5-HT(1A)R) agonist for the treatment of pain.
Ullrich A, Schneider J, Braz JM, Neu E, Staffen N, Stanek M, Bláhová J, Hove T, Albert T, Allikalt A, Löber S, Bhardwaj K, Rodriguez-Rosado S, Fink E, Rasmussen T, Hübner H, Inoue A, Shoichet BK, Basbaum AI, Böttcher B, Weikert D, Gmeiner P
Science advances 2025 Jun 20;11(25):eadv9267
Science advances 2025 Jun 20;11(25):eadv9267
Dual Role of NRF2 in Pancreatic Precursor Lesions.
Ichimiya S, Ahn SS, Dixon MS, O'Sullivan JP, DeVine LC, Chen A, Yamamoto T, Oda Y, Nakamura M, Chio IIC
Cancer research communications 2025 Jun 1;5(6):945-959
Cancer research communications 2025 Jun 1;5(6):945-959
Sympathetic nerve promotes renal fibrosis by activating M2 macrophages through β2-AR-Gsa.
Liu L, Deng Y, Li Q, Cai Y, Zhang C, Zhang T, Xu G, Han M
Clinical immunology (Orlando, Fla.) 2025 Jan;270:110397
Clinical immunology (Orlando, Fla.) 2025 Jan;270:110397
Exosomal mir-126-3p derived from endothelial cells induces ion channel dysfunction by targeting RGS3 signaling in cardiomyocytes: a novel mechanism in Takotsubo cardiomyopathy.
Fan X, Yang G, Wang Y, Shi H, Nitschke K, Sattler K, Abumayyaleh M, Cyganek L, Nuhn P, Worst T, Liao B, Dobreva G, Duerschmied D, Zhou X, El-Battrawy I, Akin I
Stem cell research & therapy 2025 Feb 4;16(1):36
Stem cell research & therapy 2025 Feb 4;16(1):36
Caloric restriction prevents inheritance of polycystic ovary syndrome through oocyte-mediated DNA methylation reprogramming.
Liu Y, Dong Y, Jiang Y, Han S, Liu X, Xu X, Zhu A, Zhao Z, Gao Y, Zou Y, Zhang C, Bian Y, Zhang Y, Liu J, Zhao S, Zhao H, Chen ZJ
Cell metabolism 2025 Apr 1;37(4):920-935.e6
Cell metabolism 2025 Apr 1;37(4):920-935.e6
Long Mu Qing Xin mixture improves behavioral performance in spontaneously hypertensive rats (SHR/NCrl) by upregulating catecholamine neurotransmitters in prefrontal cortex and striatum via DRD1/cAMP/PKA-CREB signaling pathway.
Li X, Xiao Z, Jiang Z, Pu W, Chen X, Wang S, Liu A, Zhang H, Xu Z
Frontiers in pharmacology 2024;15:1387359
Frontiers in pharmacology 2024;15:1387359
PRKDC Induces Chemoresistance in Osteosarcoma by Recruiting GDE2 to Stabilize GNAS and Activate AKT.
Zhang W, Li W, Yin C, Feng C, Liu B, Xu H, Jin X, Tu C, Li Z
Cancer research 2024 Sep 4;84(17):2873-2887
Cancer research 2024 Sep 4;84(17):2873-2887
GNAS knockout potentiates HDAC3 inhibition through viral mimicry-related interferon responses in lymphoma.
He MY, Tong KI, Liu T, Whittaker Hawkins R, Shelton V, Zeng Y, Bakhtiari M, Xiao Y, Zheng G, Sakhdari A, Yang L, Xu W, Brooks DG, Laister RC, He HH, Kridel R
Leukemia 2024 Oct;38(10):2210-2224
Leukemia 2024 Oct;38(10):2210-2224
Sex-specific transgenerational effects on murine thyroid gland imposed by ancestral exposure to neonicotinoid thiacloprid.
Diba Lahmidi M, Le Noc M, Dali O, Kernanec PY, Merret PE, Jaulin C, Smagulova F
Scientific reports 2024 Jun 6;14(1):13047
Scientific reports 2024 Jun 6;14(1):13047
A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways.
Zhang Z, Lin X, Wei L, Wu Y, Xu L, Wu L, Wei X, Zhao S, Zhu X, Xu F
Cell discovery 2024 Jan 5;10(1):3
Cell discovery 2024 Jan 5;10(1):3
Activation of melanocortin-1 receptor signaling in melanoma cells impairs T cell infiltration to dampen antitumor immunity.
Cui Y, Miao Y, Cao L, Guo L, Cui Y, Yan C, Zeng Z, Xu M, Han T
Nature communications 2023 Sep 15;14(1):5740
Nature communications 2023 Sep 15;14(1):5740
Association of elevated autoantibody to high expression of GNAS in hepatocellular carcinoma.
Wang K, Qiu C, Xing M, Li M, Wang B, Ye H, Shi J, Dai L, Wang X, Wang P
Heliyon 2023 Dec;9(12):e22627
Heliyon 2023 Dec;9(12):e22627
Gsα deficiency facilitates cardiac remodeling via CREB/ Bmp10-mediated signaling.
Yin P, Li D, Zhao Q, Cai M, Wu Z, Shi Y, Su L
Cell death discovery 2021 Dec 14;7(1):391
Cell death discovery 2021 Dec 14;7(1):391
GNAS promotes inflammation-related hepatocellular carcinoma progression by promoting STAT3 activation.
Ding H, Zhang X, Su Y, Jia C, Dai C
Cellular & molecular biology letters 2020;25:8
Cellular & molecular biology letters 2020;25:8
A novel GNAS-mutated human induced pluripotent stem cell model for understanding GNAS-mutated tumors.
Watanabe K, Nakamura T, Onodera S, Saito A, Shibahara T, Azuma T
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2020 Sep;42(9):1010428320962588
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2020 Sep;42(9):1010428320962588
Ablation of Gsa impairs renal tubule proliferation after injury via CDK2/cyclin E.
Liu L, Deng Y, Cai Y, Lu P, Guo Y, Zhang C, Li Q, Zhang T, Han M, Xu G
American journal of physiology. Renal physiology 2020 Mar 1;318(3):F793-F803
American journal of physiology. Renal physiology 2020 Mar 1;318(3):F793-F803
Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility.
Zhang DL, Sun YJ, Ma ML, Wang YJ, Lin H, Li RR, Liang ZL, Gao Y, Yang Z, He DF, Lin A, Mo H, Lu YJ, Li MJ, Kong W, Chung KY, Yi F, Li JY, Qin YY, Li J, Thomsen ARB, Kahsai AW, Chen ZJ, Xu ZG, Liu M, Li D, Yu X, Sun JP
eLife 2018 Feb 2;7
eLife 2018 Feb 2;7
HDAC2 and TXNL1 distinguish aneuploid from diploid colorectal cancers.
Gemoll T, Roblick UJ, Szymczak S, Braunschweig T, Becker S, Igl BW, Bruch HP, Ziegler A, Hellman U, Difilippantonio MJ, Ried T, Jörnvall H, Auer G, Habermann JK
Cellular and molecular life sciences : CMLS 2011 Oct;68(19):3261-74
Cellular and molecular life sciences : CMLS 2011 Oct;68(19):3261-74
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The GNAS antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human GNAS. This antibody recognizes human,mouse,rat antigen. The GNAS antibody has been validated for the following applications: ELISA, WB analysis.
