GNAS

gene product
GNAS1, GNASXL, GPSA, NESP, NESP55, SCG6, SgVI
This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012]
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719 antibodies from 40 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
59 antibodies
antibodies-online
273 antibodies
OriGene
28 antibodies
NSJ Bioreagents
2 antibodies
Santa Cruz Biotechnology
1 antibody
Invitrogen Antibodies
10 antibodies
GeneTex
4 antibodies
NovoPro Bioscience Inc.
9 antibodies
Proteintech Group
2 antibodies
Biorbyt
32 antibodies
LifeSpan BioSciences, Inc.
98 antibodies
Affinity Biosciences
2 antibodies
Aviva Systems Biology
9 antibodies
Acris Antibodies GmbH
5 antibodies
Abnova Corporation
5 antibodies
Atlas Antibodies
3 antibodies
Signalway Antibody LLC
2 antibodies
Bioworld Technology, Inc
2 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Antibodies.com
1 antibody
Boster Biological Technology
1 antibody
Everest Biotech
1 antibody
United States Biological
99 antibodies
Abgent
5 antibodies
RabMAbs
3 antibodies
ProSci
7 antibodies
Creative Biolabs
3 antibodies
MyBioSource
6 antibodies
Arigo
1 antibody
Abiocode, Inc.
3 antibodies
St John's Laboratory
3 antibodies
Creative Diagnostics
8 antibodies
Sigma-Aldrich
7 antibodies
Enzo Life Sciences
2 antibodies
RayBiotech, Inc.
2 antibodies
EMD Millipore
1 antibody
Abbexa
3 antibodies
GenWay
2 antibodies
UC Davis/NIH NeuroMab Facility
2 antibodies