15365-1-AP

antibody from Proteintech Group

Targeting: IFNG

Provider product page for 15365-1-AP

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Antibody data

Antibody Data
Antigen structure
References [96]
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Western blot [1]
Immunohistochemistry [1]

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Product number: 15365-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#15365-1-AP, RRID:AB_2123037
Product name: IFN Gamma antibody
Antibody type: Polyclonal
Description: IFN Gamma antibody (Cat. #15365-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

IFNG protein structure - 15365-1-AP shown in red.

Submitted references Construction of disulfidptosis-based immune response prediction model with artificial intelligence and validation of the pivotal grouping oncogene c-MET in regulating T cell exhaustion.

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American journal of physiology. Cell physiology 2024 May 1;326(5):C1494-C1504

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Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jun;11(23):e2401061

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Cancer letters 2024 Jul 1;593:216938

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Pharmacological research 2024 Jan;199:107053

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Molecular nutrition & food research 2024 Feb;68(3):e2300602

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Reproductive sciences (Thousand Oaks, Calif.) 2024 Feb;31(2):532-549

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Pharmacological research 2024 Feb;200:107068

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Molecular therapy : the journal of the American Society of Gene Therapy 2024 Feb 7;32(2):469-489

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International journal of molecular medicine 2023 Sep;52(3)

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Molecular immunology 2023 May;157:186-194

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Discover oncology 2023 May 8;14(1):59

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The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2023 May 1;27(3):221-230

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EBioMedicine 2023 Jan;87:104420

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Journal of neurotrauma 2023 Dec;40(23-24):2580-2595

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Li M, Gan C, Zhang R, Wang J, Wang Y, Zhu W, Liu L, Shang J, Zhao Q
Immunology 2023 Dec;170(4):495-509

IFNγ Transcribed by IRF1 in CD4+ Effector Memory T Cells Promotes Senescence-Associated Pulmonary Fibrosis.

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Oxidative medicine and cellular longevity 2022;2022:3435267

PD-L1 Inhibits T Cell-Induced Cytokines and Hyaluronan Expression via the CD40-CD40L Pathway in Orbital Fibroblasts From Patients With Thyroid Associated Ophthalmopathy.

Liu Z, Liu Y, Liu M, Gong Q, Shi A, Li X, Bai X, Guan X, Hao B, Liu F, Zhou X, Yuan H
Frontiers in immunology 2022;13:849480

CXCL10-armed oncolytic adenovirus promotes tumor-infiltrating T-cell chemotaxis to enhance anti-PD-1 therapy.

Li X, Lu M, Yuan M, Ye J, Zhang W, Xu L, Wu X, Hui B, Yang Y, Wei B, Guo C, Wei M, Dong J, Wu X, Gu Y
Oncoimmunology 2022;11(1):2118210

A Composite Hydrogel Containing Mesoporous Silica Nanoparticles Loaded With Artemisia argyi Extract for Improving Chronic Wound Healing.

Xue L, Deng T, Guo R, Peng L, Guo J, Tang F, Lin J, Jiang S, Lu H, Liu X, Deng L
Frontiers in bioengineering and biotechnology 2022;10:825339

A bioactive dextran-based hydrogel promote the healing of infected wounds via antibacterial and immunomodulatory.

Zhou L, Zhou L, Wei C, Guo R
Carbohydrate polymers 2022 Sep 1;291:119558

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Wang Y, Wang C, Chen H, Zhang Y, Gao N, Yu Y, Xing Y, Xie L, Wang Z, Cai Y
Acta tropica 2022 Oct;234:106629

LFA-1/ ICAM-1 promotes NK cell cytotoxicity associated with the pathogenesis of ocular toxoplasmosis in murine model.

Gao N, Wang C, Yu Y, Xie L, Xing Y, Zhang Y, Wang Y, Wu J, Cai Y
PLoS neglected tropical diseases 2022 Oct;16(10):e0010848

An improved cell line-derived xenograft humanized mouse model for evaluation of PD-1/PD-L1 blocker BMS202-induced immune responses in colorectal cancer.

Shang P, Yu L, Cao S, Guo C, Zhang W
Acta biochimica et biophysica Sinica 2022 Oct 25;54(10):1497-1506

Aberrant hyperexpression of the RNA binding protein FMRP in tumors mediates immune evasion.

Zeng Q, Saghafinia S, Chryplewicz A, Fournier N, Christe L, Xie YQ, Guillot J, Yucel S, Li P, Galván JA, Karamitopoulou E, Zlobec I, Ataca D, Gallean F, Zhang P, Rodriguez-Calero JA, Rubin M, Tichet M, Homicsko K, Hanahan D
Science (New York, N.Y.) 2022 Nov 18;378(6621):eabl7207

Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.

Fan TW, Daneshmandi S, Cassel TA, Uddin MB, Sledziona J, Thompson PT, Lin P, Higashi RM, Lane AN
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690

Enhanced immunogenicity of the tuberculosis subunit Rv0572c vaccine delivered in DMT liposome adjuvant as a BCG-booster.

Mao L, Xu L, Wang X, Xing Y, Wang J, Zhang Y, Yuan W, Du J, Shi Z, Ma J, Zhang J, Zhang X, Wang X
Tuberculosis (Edinburgh, Scotland) 2022 May;134:102186

Exosomal circGSE1 promotes immune escape of hepatocellular carcinoma by inducing the expansion of regulatory T cells.

Huang M, Huang X, Huang N
Cancer science 2022 Jun;113(6):1968-1983

Human lung adenocarcinoma CD47 is upregulated by interferon-γ and promotes tumor metastasis.

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Molecular therapy oncolytics 2022 Jun 16;25:276-287

Combinational Deletions of MGF360-9L and MGF505-7R Attenuated Highly Virulent African Swine Fever Virus and Conferred Protection against Homologous Challenge.

Ding M, Dang W, Liu H, Xu F, Huang H, Sunkang Y, Li T, Pei J, Liu X, Zhang Y, Zheng H
Journal of virology 2022 Jul 27;96(14):e0032922

A Novel Rat Model of Dry Eye Induced by Aerosol Exposure of Particulate Matter.

Mu N, Wang H, Chen D, Wang F, Ji L, Zhang C, Li M, Lu P
Investigative ophthalmology & visual science 2022 Jan 3;63(1):39

Delivery of germacrone (GER) using macrophages-targeted polymeric nanoparticles and its application in rheumatoid arthritis.

Tan T, Huang Q, Chu W, Li B, Wu J, Xia Q, Cao X
Drug delivery 2022 Dec;29(1):692-701

Design, synthesis and evaluation of fused hybrids with acetylcholinesterase inhibiting and Nrf2 activating functions for Alzheimer's disease.

Wang Y, Xiong B, Lin H, Li Q, Yang H, Qiao Y, Li Q, Xu Z, Lyu W, Qu W, Liu W, Chen Y, Feng F, Sun H
European journal of medicinal chemistry 2022 Dec 15;244:114806

EGFR-phosphorylated GDH1 harmonizes with RSK2 to drive CREB activation and tumor metastasis in EGFR-activated lung cancer.

Kang J, Chun J, Hwang JS, Pan C, Li J, Boese AC, Young I, Malin CM, Kang Y, Gibbons DL, Sica G, Fu H, Ramalingam SS, Jin L, Kang S
Cell reports 2022 Dec 13;41(11):111827

Augmented PFKFB3-mediated glycolysis by interferon-γ promotes inflammatory M1 polarization through the JAK2/STAT1 pathway in local vascular inflammation in Takayasu arteritis.

Chen R, Wang J, Dai X, Wu S, Huang Q, Jiang L, Kong X
Arthritis research & therapy 2022 Dec 12;24(1):266

MEF2C promotes M1 macrophage polarization and Th1 responses.

Zhao X, Di Q, Liu H, Quan J, Ling J, Zhao Z, Xiao Y, Wu H, Wu Z, Song W, An H, Chen W
Cellular & molecular immunology 2022 Apr;19(4):540-553

Lactobacillus acidophilus ATCC 4356 Alleviates Renal Ischemia-Reperfusion Injury Through Antioxidant Stress and Anti-inflammatory Responses and Improves Intestinal Microbial Distribution.

Zhang P, Han X, Zhang X, Zhu X
Frontiers in nutrition 2021;8:667695

Alterations in CD8(+) Tregs, CD56(+) Natural Killer Cells and IL-10 Are Associated With Invasiveness of Nonfunctioning Pituitary Adenomas (NFPAs).

Huang X, Xu J, Wu Y, Sheng L, Li Y, Zha B, Sun T, Yang J, Zang S, Liu J
Pathology oncology research : POR 2021;27:598887

Encapsulation of LXR ligand by D-Nap-GFFY hydrogel enhances anti-tumorigenic actions of LXR and removes LXR-induced lipogenesis.

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Theranostics 2021;11(6):2634-2654

The Role of Tim-3 on dNK Cells Dysfunction During Abnormal Pregnancy With Toxoplasma gondii Infection.

Li T, Cui L, Xu X, Zhang H, Jiang Y, Ren L, Yang C, Liu X, Hu X
Frontiers in cellular and infection microbiology 2021;11:587150

Self-assembled FeS-based cascade bioreactor with enhanced tumor penetration and synergistic treatments to trigger robust cancer immunotherapy.

Ren H, Yong J, Yang Q, Yang Z, Liu Z, Xu Y, Wang H, Jiang X, Miao W, Li X
Acta pharmaceutica Sinica. B 2021 Oct;11(10):3244-3261

Inhibition of NLRP3 inflammasome activation in myeloid-derived suppressor cells by andrographolide sulfonate contributes to 5-FU sensitization in mice.

Xu L, Cai P, Li X, Wu X, Gao J, Liu W, Yang J, Xu Q, Guo W, Gu Y
Toxicology and applied pharmacology 2021 Oct 1;428:115672

Targeting regulator of G protein signaling 1 in tumor-specific T cells enhances their trafficking to breast cancer.

Huang D, Chen X, Zeng X, Lao L, Li J, Xing Y, Lu Y, Ouyang Q, Chen J, Yang L, Su F, Yao H, Liu Q, Su S, Song E
Nature immunology 2021 Jul;22(7):865-879

The role of IP-10 and its receptor CXCR3 in early pregnancy.

Jiang Y, Huang F, Chai X, Yuan W, Ding H, Wu X
Molecular immunology 2021 Dec;140:59-69

IL-27 Rα(+) cells promoted allorejection via enhancing STAT1/3/5 phosphorylation.

Zhao S, Liang T, Zhang C, Shi D, Jiang W, Su C, Hou G
Journal of cellular and molecular medicine 2020 Sep;24(18):10756-10767

Apatinib enhanced anti-PD-1 therapy for colon cancer in mice via promoting PD-L1 expression.

Cai X, Wei B, Li L, Chen X, Liu W, Cui J, Lin Y, Sun Y, Xu Q, Guo W, Gu Y
International immunopharmacology 2020 Nov;88:106858

Maladjustment of β-CGRP/α-CGRP Regulation of AQP5 Promotes Transition of Alveolar Epithelial Cell Apoptosis to Pulmonary Fibrosis.

Lv X, Gao F, Zhang S, Zhang S, Zhou X, Ding F, Wang J, Chen Q, Chen M, Liu Q
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2020 Aug;40(8):377-388

Anti-inflammatory effects of α-MSH through p-CREB expression in sarcoidosis like granuloma model.

Zhang C, Chery S, Lazerson A, Altman NH, Jackson R, Holt G, Campos M, Schally AV, Mirsaeidi M
Scientific reports 2020 Apr 29;10(1):7277

Total Glycosides of Peony Protects Against Inflammatory Bowel Disease by Regulating IL-23/IL-17 Axis and Th17/Treg Balance.

Li Q, Shan Q, Sang X, Zhu R, Chen X, Cao G
The American journal of Chinese medicine 2019;47(1):177-201

Dehydroepiandrosterone stimulates inflammation and impairs ovarian functions of polycystic ovary syndrome.

Li Y, Zheng Q, Sun D, Cui X, Chen S, Bulbul A, Liu S, Yan Q
Journal of cellular physiology 2019 May;234(5):7435-7447

Low-Dose IFNγ Induces Tumor Cell Stemness in Tumor Microenvironment of Non-Small Cell Lung Cancer.

Song M, Ping Y, Zhang K, Yang L, Li F, Zhang C, Cheng S, Yue D, Maimela NR, Qu J, Liu S, Sun T, Li Z, Xia J, Zhang B, Wang L, Zhang Y
Cancer research 2019 Jul 15;79(14):3737-3748

Macrophage polarization in human gingival tissue in response to periodontal disease.

Zhou LN, Bi CS, Gao LN, An Y, Chen F, Chen FM
Oral diseases 2019 Jan;25(1):265-273

Using IFN-γ antibodies to identify the pathogens of fungal rhinosinusitis: A novel immunohistochemical approach.

Yan Y, Zhao Z, Dong G, Han Y, Yang D, Yin H, Piao Y, He C, Tian C, Wan H, Li X, Jin Y, Fang J, Liu H
Molecular medicine reports 2018 Mar;17(3):3627-3632

A comparison of CRISPR/Cas9 and siRNA-mediated ALDH2 gene silencing in human cell lines.

Wang F, Guo T, Jiang H, Li R, Wang T, Zeng N, Dong G, Zeng X, Li D, Xiao Y, Hu Q, Chen W, Xing X, Wang Q
Molecular genetics and genomics : MGG 2018 Jun;293(3):769-783

PD-1 axis expression in musculoskeletal tumors and antitumor effect of nivolumab in osteosarcoma model of humanized mouse.

Zheng B, Ren T, Huang Y, Sun K, Wang S, Bao X, Liu K, Guo W
Journal of hematology & oncology 2018 Feb 6;11(1):16

Activation of liver X receptor plays a central role in antiviral actions of 25-hydroxycholesterol.

Liu Y, Wei Z, Zhang Y, Ma X, Chen Y, Yu M, Ma C, Li X, Cao Y, Liu J, Han J, Yang X, Duan Y
Journal of lipid research 2018 Dec;59(12):2287-2296

Xin-Jia-Xiang-Ru-Yin alleviated H1N1-induced acute lung injury and inhibited the IFN-γ-related regulatory pathway in summer flu.

Li Q, Pang P, Zheng K, Sun L, Wang J, Chen X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Dec;108:201-207

Toll-Like Receptor 4-Myeloid Differentiation Primary Response Gene 88 Pathway Is Involved in the Inflammatory Development of Polymyositis by Mediating Interferon-γ and Interleukin-17A in Humans and Experimental Autoimmune Myositis Mouse Model.

Zhang H, He F, Shi M, Wang W, Tian X, Kang J, Han W, Wu R, Zhou L, Hu M, Li X, Mi F, Zhao G, Jia H
Frontiers in neurology 2017;8:132

Tumor PD-L1 expression is correlated with increased TILs and poor prognosis in penile squamous cell carcinoma.

Deng C, Li Z, Guo S, Chen P, Chen X, Zhou Q, Chen J, Yu X, Wu X, Ma W, Xie Q, Ye Y, Li Y, Qin Z, Liu Z, Liu R, Zhang Z, Yao K, Han H, Zhou F
Oncoimmunology 2017;6(2):e1269047

The natural product fucoidan ameliorates hepatic ischemia-reperfusion injury in mice.

Li J, Zhang Q, Li S, Dai W, Feng J, Wu L, Liu T, Chen K, Xia Y, Lu J, Zhou Y, Fan X, Guo C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Oct;94:687-696

The liver protection of propylene glycol alginate sodium sulfate preconditioning against ischemia reperfusion injury: focusing MAPK pathway activity.

Xu S, Niu P, Chen K, Xia Y, Yu Q, Liu N, Li J, Li S, Wu L, Feng J, Wang W, Lu X, Liu T, Wang F, Dai W, Fan X, Mo W, Xu L, Guo C
Scientific reports 2017 Nov 9;7(1):15175

Orbital fibroblasts of Graves' orbitopathy stimulated with proinflammatory cytokines promote B cell survival by secreting BAFF.

Tang F, Chen X, Mao Y, Wan S, Ai S, Yang H, Liu G, Zou Y, Lin M, Dan L
Molecular and cellular endocrinology 2017 May 5;446:1-11

Enteric dysbiosis-linked gut barrier disruption triggers early renal injury induced by chronic high salt feeding in mice.

Hu J, Luo H, Wang J, Tang W, Lu J, Wu S, Xiong Z, Yang G, Chen Z, Lan T, Zhou H, Nie J, Jiang Y, Chen P
Experimental & molecular medicine 2017 Aug 25;49(8):e370

Disruption of Tumor Necrosis Factor Receptor-Associated Factor 5 Exacerbates Murine Experimental Colitis via Regulating T Helper Cell-Mediated Inflammation.

Shang J, Li L, Wang X, Pan H, Liu S, He R, Li J, Zhao Q
Mediators of inflammation 2016;2016:9453745

MEK1/2 inhibitors induce interleukin-5 expression in mouse macrophages and lymphocytes.

Li X, Cao X, Zhang X, Kang Y, Zhang W, Yu M, Ma C, Han J, Duan Y, Chen Y
Biochemical and biophysical research communications 2016 May 13;473(4):939-946

Activation of liver X receptor inhibits the development of pulmonary carcinomas induced by 3-methylcholanthrene and butylated hydroxytoluene in BALB/c mice.

Wang Q, Sun L, Yang X, Ma X, Li Q, Chen Y, Liu Y, Zhang D, Li X, Xiang R, Wei Y, Han J, Duan Y
Scientific reports 2016 Jun 2;6:27295

Effect of IL-17 in the development of colon cancer in mice.

Yang L, Liu H, Zhang L, Hu J, Chen H, Wang L, Yin X, Li Q, Qi Y
Oncology letters 2016 Dec;12(6):4929-4936

A fundamental study on the dynamics of multiple biomarkers in mouse excisional wounds for wound age estimation.

Wang LL, Zhao R, Liu CS, Liu M, Li SS, Li JY, Jiang SK, Zhang M, Tian ZL, Wang M, Zhang MZ, Guan DW
Journal of forensic and legal medicine 2016 Apr;39:138-46

Anti-inflammatory effect of topical administration of tofacitinib on corneal inflammation.

Sakimoto T, Ishimori A
Experimental eye research 2016 Apr;145:110-117

The quantum of initial transformed cells potentially modulates the type of local inflammation mechanism elicited by surrounding normal epithelial tissues and systemic immune pattern for tumor arrest or progression.

Owusu L, Wang B, Du Y, Li W, Xin Y
Journal of Cancer 2015;6(2):128-38

Inhibition of tumor growth by U0126 is associated with induction of interferon-γ production.

Ma X, Wang Q, Liu Y, Chen Y, Zhang L, Jiang M, Li X, Xiang R, Miao RQ, Duan Y, Han J
International journal of cancer 2015 Feb 15;136(4):771-83

PTPROt maintains T cell immunity in the microenvironment of hepatocellular carcinoma.

Hou J, Deng L, Zhuo H, Lin Z, Chen Y, Jiang R, Chen D, Zhang X, Huang X, Sun B
Journal of molecular cell biology 2015 Aug;7(4):338-50

Decreased percentages of regulatory T cells are necessary to activate Th1-Th17-Th22 responses during acute rejection of the peripheral nerve xenotransplantation in mice.

Chai H, Yang L, Gao L, Guo Y, Li H, Fan X, Wu B, Xue S, Cai Y, Jiang X, Qin B, Zhang S, Ke Y
Transplantation 2014 Oct 15;98(7):729-37

Echinococcus granulosus infection reduces airway inflammation of mice likely through enhancing IL-10 and down-regulation of IL-5 and IL-17A.

Wang H, Li J, Pu H, Hasan B, Ma J, Jones MK, Zheng K, Zhang X, Ma H, McManus DP, Lin R, Wen H, Zhang W
Parasites & vectors 2014 Nov 20;7:522

Identification of interferon-γ as a new molecular target of liver X receptor.

Wang Q, Ma X, Chen Y, Zhang L, Jiang M, Li X, Xiang R, Miao R, Hajjar DP, Duan Y, Han J
The Biochemical journal 2014 Apr 15;459(2):345-54

A novel role of IGFBP7 in mouse uterus: regulating uterine receptivity through Th1/Th2 lymphocyte balance and decidualization.

Liu ZK, Wang RC, Han BC, Yang Y, Peng JP
PloS one 2012;7(9):e45224

Interferon-γ-stimulated genes, but not USP18, are expressed in livers of patients with acute hepatitis C.

Dill MT, Makowska Z, Duong FHT, Merkofer F, Filipowicz M, Baumert TF, Tornillo L, Terracciano L, Heim MH
Gastroenterology 2012 Sep;143(3):777-786.e6

Implications of Th1 and Th17 cells in pathogenesis of oral lichen planus.

Xie S, Ding L, Xiong Z, Zhu S
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2012 Jun;32(3):451-457

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse thymus tissue were subjected to SDS PAGE followed by western blot with 15365-1-AP(IFNG antibody) at dilution of 1:800
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The interferon-gamma antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human interferon-gamma. This antibody recognizes human, mouse antigen. The interferon-gamma antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 15365-1-AP.pdf

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