IFNG

This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]

Description

interferon gamma

Protein family

Cancer-related genes, Disease related genes, FDA approved drug targets, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted secreted proteins, Protein evidence (Peptideatlas)

Chromosome

12:q15 (68154768 - 68159740)

Ensembl ID

ENSG00000111537  (ver. 99.38)

Orthologs

Mouse Ifng: ENSMUSG00000055170

UniProt

P01579

neXtProt

NX_P01579

Human splice variants
Mouse splice variants