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- Antibody Data
- Antigen structure
- References [5]
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- Product number
- ABIN493470 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Suppressor of Cytokine Signaling 1 (SOCS1) antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptides corresponding to unique epitope on SOCS1. The SOCS1 peptide was post-synthetically covalently modified to achieve desired antigenicity.
- Description
- Affinity Chromatography on immobilized antigen
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 mg
- Concentration
- 0.64-0.72 mg/mL
- Storage
- Store the antibody undiluted (in aliquots) at-20°C.
- Handling
- Avoid repeated freezing and thawing.
Submitted references SOCS1 protects protein tyrosine phosphatases by thioredoxin upregulation and attenuates Jaks to suppress ROS-mediated apoptosis.
Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation.
SOCS-1 localizes to the microtubule organizing complex-associated 20S proteasome.
Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively.
A family of cytokine-inducible inhibitors of signalling.
Oh J, Hur MW, Lee CE
Oncogene 2009 Sep 3;28(35):3145-56
Oncogene 2009 Sep 3;28(35):3145-56
Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation.
Weniger MA, Melzner I, Menz CK, Wegener S, Bucur AJ, Dorsch K, Mattfeldt T, Barth TF, Möller P
Oncogene 2006 Apr 27;25(18):2679-84
Oncogene 2006 Apr 27;25(18):2679-84
SOCS-1 localizes to the microtubule organizing complex-associated 20S proteasome.
Vuong BQ, Arenzana TL, Showalter BM, Losman J, Chen XP, Mostecki J, Banks AS, Limnander A, Fernandez N, Rothman PB
Molecular and cellular biology 2004 Oct;24(20):9092-101
Molecular and cellular biology 2004 Oct;24(20):9092-101
Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively.
Yandava CN, Pillari A, Drazen JM
Genomics 1999 Oct 1;61(1):108-11
Genomics 1999 Oct 1;61(1):108-11
A family of cytokine-inducible inhibitors of signalling.
Starr R, Willson TA, Viney EM, Murray LJ, Rayner JR, Jenkins BJ, Gonda TJ, Alexander WS, Metcalf D, Nicola NA, Hilton DJ
Nature 1997 Jun 26;387(6636):917-21
Nature 1997 Jun 26;387(6636):917-21
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