SOCS1

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]

Description

Suppressor of cytokine signaling 1

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Cytoplasmic bodies

Predicted location

Intracellular

Protein family

Cancer-related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

16 (11254408 - 11256204)

Ensembl ID

ENSG00000185338  (ver. 103.38)

Orthologs

Mouse Socs1: ENSMUSG00000038037

UniProt

O15524

neXtProt

NX_O15524

Human splice variants
Mouse splice variants

Protein structure