Ab128582

antibody from Aladdin Scientific

Targeting: SOCS1 Cish1, JAB, SOCS-1, SSI-1, TIP3

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Validation data

Product number: Ab128582 - Provider product page
Provider: Aladdin Scientific
Product name: SOCS1 Antibody
Antibody type: Polyclonal
Description: Rabbit anti Human SOCS1 Antibody, Polyclonal antibody, could be used for WB, IHC and so on.Application:WB: 1/500-1/1000IHC: 1/50-1/100Protein FunctionSOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Antigen sequence: AA 149-211
Vial size: 100_l,10_l,1ml,50_l
Concentration: 0,7 mg/ml
Storage: Store at 4¡C short term (1-2 weeks). Store at -20¡C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

SOCS1 protein structure - Ab128582 shown in red.