Antibody data
- Antibody Data
- Antigen structure
- References [25]
- Comments [0]
- Validations [0]
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- Product number
- 27398-1-AP - Provider product page

- Provider
- Proteintech Group
- Product name
- PRKACA antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PRKACA antibody (Cat. #27398-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Novel BLT1 inhibitor baeckein E ameliorates LPS-induced acute lung injury through ferroptosis inhibition.
Astragaloside IV alleviates post-traumatic cytotoxic edema via inhibition of AQP4 expression and subcellular localization.
Mechanistic study on Kai Xin San's regulation of DARPP-32 phosphorylation in anti-depressant effects based on multi-omics.
GJB2 drives LUAD progression in part via cAMP-mediated M2 macrophage polarization through the PKA-CREB pathway.
Overexpression of GPER1 suppressed esophageal carcinoma growth via activating cAMP pathway.
Intrathecal injection of rituximab inhibits microglial M1 polarisation to alleviate neuropsychiatric SLE symptoms via the cAMP/PKA/CREB signalling pathway.
Thermosensitive hydrogel delivers nanoparticles for the modulation of immune homeostasis for salpingitis therapy.
Wheat grain moxibustion ameliorates oxidative stress in PTU-induced hypothyroid rats via cAMP/PKA pathway activation.
Exercise attenuates hepatic ectopic lipid deposition in high fat-diet rats via PKA-mediated phosphorylation of Perilipin5.
E3 ubiquitin ligase CHIP facilitates cAMP and cGMP signalling cross-talk by polyubiquitinating PDE9A.
GZMA suppressed GPX4-mediated ferroptosis to improve intestinal mucosal barrier function in inflammatory bowel disease.
Paeonol and glycyrrhizic acid in combination ameliorate the recurrent nitroglycerin-induced migraine-like phenotype in rats by regulating the GABBR2/TRPM8/PRKACA/TRPV1 pathway.
AKAP1 alleviates VSMC phenotypic modulation and neointima formation by inhibiting Drp1-dependent mitochondrial fission.
Molecular mechanism of Chang Shen Hua volatile oil modulating brain cAMP-PKA-CREB pathway to improve depression-like behavior in rats.
Protection of p-Coumaric acid against chronic stress-induced neurobehavioral deficits in mice via activating the PKA-CREB-BDNF pathway.
Zexieyin formula alleviates Alzheimer's disease via post-synaptic CaMKII modulating AMPA receptor: Involved in promoting neurogenesis to strengthen synaptic plasticity in mice hippocampus.
Vitronectin Destroyed Intestinal Epithelial Cell Differentiation through Activation of PDE4-Mediated Ferroptosis in Inflammatory Bowel Disease.
Integrating Network Pharmacology, Molecular Docking and Pharmacological Evaluation for Exploring the Polyrhachis vicina Rogers in Ameliorating Depression.
Phosphoproteomic and proteomic profiling in post-infarction chronic heart failure.
Theaflavine inhibits hepatic stellate cell activation by modulating the PKA/LKB1/AMPK/GSK3β cascade and subsequently enhancing Nrf2 signaling.
Mitoguardin2 Is Associated With Hyperandrogenism and Regulates Steroidogenesis in Human Ovarian Granulosa Cells.
Histone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting.
Study of differential proteomics in granulosa cells of premature ovarian insufficiency (POI) and the roles and mechanism of RAC1 in granulosa cells.
Avian Hepatitis E Virus ORF2 Protein Interacts with Rap1b to Induce Cytoskeleton Rearrangement That Facilitates Virus Internalization.
Protein modifications throughout the lung cancer proteome unravel the cancer-specific regulation of glycolysis.
Mi Y, Wang R, Qian J, Liu Z, Li Y, Fan H, Wang L, Kuai H, Xiong F, Wang H, Shi X, Hu X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158147
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158147
Astragaloside IV alleviates post-traumatic cytotoxic edema via inhibition of AQP4 expression and subcellular localization.
Shen W, Jiang C, Liu X, Wang D, Li G, Hui Y, Ding Y, Li C, Shao B, Hou B
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158096
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158096
Mechanistic study on Kai Xin San's regulation of DARPP-32 phosphorylation in anti-depressant effects based on multi-omics.
Shan M, Xu L, Dong J, Zhang X, Fang X, Luo H
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120746
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120746
GJB2 drives LUAD progression in part via cAMP-mediated M2 macrophage polarization through the PKA-CREB pathway.
Liu Y, Liu G, Mei J, Li J, Si J, Kang Y, Jin J
Respiratory research 2026 Jan 30;27(1)
Respiratory research 2026 Jan 30;27(1)
Overexpression of GPER1 suppressed esophageal carcinoma growth via activating cAMP pathway.
Yin H, Han X, Zhang Q, Li D, Wang F
European journal of histochemistry : EJH 2026 Jan 26;70(1)
European journal of histochemistry : EJH 2026 Jan 26;70(1)
Intrathecal injection of rituximab inhibits microglial M1 polarisation to alleviate neuropsychiatric SLE symptoms via the cAMP/PKA/CREB signalling pathway.
Li C, Yu W, Li A, Chen Y, Zhao J, Lin Y, Pan XL, Tian M
Lupus science & medicine 2026 Feb 16;13(1)
Lupus science & medicine 2026 Feb 16;13(1)
Thermosensitive hydrogel delivers nanoparticles for the modulation of immune homeostasis for salpingitis therapy.
Zhang X, Wang S, Chen X, Luo H, Wang J, Wang S, Long Z, He B, Xu X, Yu X, Zheng Y
Acta biomaterialia 2026 Apr;214:210-225
Acta biomaterialia 2026 Apr;214:210-225
Wheat grain moxibustion ameliorates oxidative stress in PTU-induced hypothyroid rats via cAMP/PKA pathway activation.
Qin J, Liu T, Zhang X, Chen X, Qin J, Aslam MS, Feng H, Zhang Y, Wang X, Zhang T, Hao C
Frontiers in endocrinology 2025;16:1612008
Frontiers in endocrinology 2025;16:1612008
Exercise attenuates hepatic ectopic lipid deposition in high fat-diet rats via PKA-mediated phosphorylation of Perilipin5.
Dong S, Yang Y, Li W, Wang L, Li T
Scientific reports 2025 Nov 27;15(1):42466
Scientific reports 2025 Nov 27;15(1):42466
E3 ubiquitin ligase CHIP facilitates cAMP and cGMP signalling cross-talk by polyubiquitinating PDE9A.
Hao X, Hu Z, Li M, Zhang S, Tang M, Hao C, Qi S, Liang Y, Almeida MF, Smith K, Zuo C, Feng Y, Guo M, Ma D, Li S, Wang Z, Sun Y, Deng Z, Mao C, Xia Z, Jiang Y, Gao Y, Xu Y, Schisler JC, Shi C
The EMBO journal 2025 Feb;44(4):1249-1273
The EMBO journal 2025 Feb;44(4):1249-1273
GZMA suppressed GPX4-mediated ferroptosis to improve intestinal mucosal barrier function in inflammatory bowel disease.
Niu R, Lan J, Liang D, Xiang L, Wu J, Zhang X, Li Z, Chen H, Geng L, Xu W, Gong S, Yang M
Cell communication and signaling : CCS 2024 Oct 4;22(1):474
Cell communication and signaling : CCS 2024 Oct 4;22(1):474
Paeonol and glycyrrhizic acid in combination ameliorate the recurrent nitroglycerin-induced migraine-like phenotype in rats by regulating the GABBR2/TRPM8/PRKACA/TRPV1 pathway.
Zhang Y, Ge F, Luo Y, Ji X, Liu Z, Qiu Y, Hou J, Zhou R, Zhao C, Xu Q, Zhang S, Yu X, Wang C, Ge D, Meng F, Tao X
Journal of ethnopharmacology 2024 Nov 15;334:118464
Journal of ethnopharmacology 2024 Nov 15;334:118464
AKAP1 alleviates VSMC phenotypic modulation and neointima formation by inhibiting Drp1-dependent mitochondrial fission.
Sun J, Shao Y, Pei L, Zhu Q, Yu X, Yao W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jul;176:116858
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jul;176:116858
Molecular mechanism of Chang Shen Hua volatile oil modulating brain cAMP-PKA-CREB pathway to improve depression-like behavior in rats.
Zhang S, Hu Y, Zhao Y, Feng Y, Wang X, Miao M, Miao J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155729
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155729
Protection of p-Coumaric acid against chronic stress-induced neurobehavioral deficits in mice via activating the PKA-CREB-BDNF pathway.
Cao Y, Chen H, Tan Y, Yu XD, Xiao C, Li Y, Reilly J, He Z, Shu X
Physiology & behavior 2024 Jan 1;273:114415
Physiology & behavior 2024 Jan 1;273:114415
Zexieyin formula alleviates Alzheimer's disease via post-synaptic CaMKII modulating AMPA receptor: Involved in promoting neurogenesis to strengthen synaptic plasticity in mice hippocampus.
Sun Y, Zhang H, Liu R, Wang Y, Zhang X, Huang R, Zhu B, Wu H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Aug;131:155802
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Aug;131:155802
Vitronectin Destroyed Intestinal Epithelial Cell Differentiation through Activation of PDE4-Mediated Ferroptosis in Inflammatory Bowel Disease.
Pan W, Xiang L, Liang X, Du W, Zhao J, Zhang S, Zhou X, Geng L, Gong S, Xu W
Mediators of inflammation 2023;2023:6623329
Mediators of inflammation 2023;2023:6623329
Integrating Network Pharmacology, Molecular Docking and Pharmacological Evaluation for Exploring the Polyrhachis vicina Rogers in Ameliorating Depression.
He J, Han D, Jia C, Xie J, Zhu F, Wei J, Li D, Wei D, Li Y, Tang L, Wei G, Yan J, Tong Y, Yang L, Tan X
Drug design, development and therapy 2023;17:717-735
Drug design, development and therapy 2023;17:717-735
Phosphoproteomic and proteomic profiling in post-infarction chronic heart failure.
Wang J, Zhu X, Wang S, Zhang Y, Hua W, Liu Z, Zheng Y, Lu X
Frontiers in pharmacology 2023;14:1181622
Frontiers in pharmacology 2023;14:1181622
Theaflavine inhibits hepatic stellate cell activation by modulating the PKA/LKB1/AMPK/GSK3β cascade and subsequently enhancing Nrf2 signaling.
Shu G, Sun H, Zhang T, Zhu A, Lei X, Wang C, Song A, Deng X
European journal of pharmacology 2023 Oct 5;956:175964
European journal of pharmacology 2023 Oct 5;956:175964
Mitoguardin2 Is Associated With Hyperandrogenism and Regulates Steroidogenesis in Human Ovarian Granulosa Cells.
Yan MQ, Wang Y, Wang Z, Liu XH, Yang YM, Duan XY, Sun H, Liu XM
Journal of the Endocrine Society 2023 Mar 6;7(5):bvad034
Journal of the Endocrine Society 2023 Mar 6;7(5):bvad034
Histone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting.
Zhao Y, Li S, Chen Y, Wang Y, Wei Y, Zhou T, Zhang Y, Yang Y, Chen L, Liu Y, Hu C, Zhou B, Ding Q
Molecular cell 2023 Apr 6;83(7):1093-1108.e8
Molecular cell 2023 Apr 6;83(7):1093-1108.e8
Study of differential proteomics in granulosa cells of premature ovarian insufficiency (POI) and the roles and mechanism of RAC1 in granulosa cells.
Zhang QY, Li X, Zhou XY, Li Y, Zhang J, Zhang XF, Liu YD, Chen YX, Wu XM, Ma LZ, Chen X, Chen SL
Molecular and cellular endocrinology 2022 Sep 15;555:111719
Molecular and cellular endocrinology 2022 Sep 15;555:111719
Avian Hepatitis E Virus ORF2 Protein Interacts with Rap1b to Induce Cytoskeleton Rearrangement That Facilitates Virus Internalization.
Zhang B, Fan M, Fan J, Luo Y, Wang J, Wang Y, Liu B, Sun Y, Zhao Q, Hiscox JA, Nan Y, Zhou EM
Microbiology spectrum 2022 Feb 23;10(1):e0226521
Microbiology spectrum 2022 Feb 23;10(1):e0226521
Protein modifications throughout the lung cancer proteome unravel the cancer-specific regulation of glycolysis.
Duan Y, Li J, Wang F, Wei J, Yang Z, Sun M, Liu J, Wen M, Huang W, Chen Z, Lu Z, Yang JH, Wei G
Cell reports 2021 Dec 21;37(12):110137
Cell reports 2021 Dec 21;37(12):110137
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