PRKACA

gene product
PKACa
This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms. [provided by RefSeq, Jan 2015]
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507 antibodies from 39 providers.

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Antibody
Proteintech Group
4 antibodies
Abnova Corporation
10 antibodies
GeneTex
5 antibodies
antibodies-online
178 antibodies
Santa Cruz Biotechnology
1 antibody
Aviva Systems Biology
8 antibodies
Biorbyt
41 antibodies
Invitrogen Antibodies
9 antibodies
OriGene
14 antibodies
LifeSpan BioSciences, Inc.
59 antibodies
Affinity Biosciences
7 antibodies
Acris Antibodies GmbH
12 antibodies
NovoPro Bioscience Inc.
4 antibodies
Abgent
4 antibodies
Cell Signaling Technology, Inc
4 antibodies
Novus Biologicals
27 antibodies
ProSci
2 antibodies
HUABIO Research
1 antibody
Atlas Antibodies
1 antibody
RabMAbs
5 antibodies
Signalway Antibody LLC
1 antibody
St John's Laboratory
9 antibodies
Abbkine Scientific Co.Ltd.
4 antibodies
Antibodies.com
3 antibodies
Arigo
2 antibodies
NSJ Bioreagents
2 antibodies
Creative Diagnostics
10 antibodies
MyBioSource
15 antibodies
Bioworld Technology, Inc
3 antibodies
R&D Systems
3 antibodies
Creative Biolabs
11 antibodies
RayBiotech, Inc.
2 antibodies
United States Biological
18 antibodies
Abbexa
14 antibodies
Boster Biological Technology
1 antibody
Leading Biology
4 antibodies
Sigma-Aldrich
2 antibodies
GenWay
5 antibodies
EMD Millipore
2 antibodies