12232-1-AP

antibody from Proteintech Group

Targeting: PRKACB PKACb

Provider product page for 12232-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [13]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [1]

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Product number: 12232-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#12232-1-AP, RRID:AB_2170177
Product name: PRKACB antibody
Antibody type: Polyclonal
Description: PRKACB antibody (Cat. #12232-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PRKACB protein structure - 12232-1-AP shown in red.

Submitted references Osmotic Tension Asymmetry Drives Electrotactic Migration via PDLIM7-Polarized Microfilament Coordination in Breast Cancer Cells.

Zhu L, Zheng Z, Li W, Shou C, Zhao Y, Zhang L, Shi X, Hu Y, Zhao H, Wu H, Guo J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(13):e15246

Alpha-estradiol and (R)-(-)-ibuprofen inhibit gastric cancer progression via GLI1 G-quadruplex.

Li Q, Pan P, Xian Q, Li J, Wang J, Cai J, Wang J, Jia Y, Sun H, Zhang L, Ma X
Frontiers in pharmacology 2025;16:1492694

Myristoylated Eepd1 Enhances Lipolysis and Thermogenesis through PKA Activation to Combat Obesity.

Chen S, Wang Y, Zhou Q, Qian Q, Jiang Q, Liu C, Liu Y, Zhou P, Xiong J, Zhang Y, Wang N, Li YE, Yin L, Yang H, Liu J
Nature communications 2025 Jan 14;16(1):651

1-NP hijacks endocrine-metabolic checkpoints and disrupts testicular steroidogenesis by suppressing the cAMP-PKA-CREB-HMGCR axis.

Zhu XX, Zhang WW, Hao MY, Chen ZY, Wan BF, Niu MH, Li XL, Wei JH, Liu SY, Mi SL, Wang H, Xu DX, Gao L
Toxicology letters 2025 Dec;414:111781

The cAMP-PKA signaling initiates mitosis by phosphorylating Bora.

Zhu M, Zhou S, Zhang Y, Chen Q, Yuan X, Zhang L, Yan H, Wang F
Nature communications 2025 Aug 24;16(1):7898

Taxifolin attenuates liver fibrosis by regulating the phosphorylation of NDRG1 at Thr328 via hepatocyte-stellate cell cross talk.

Ding C, Wang Z, Shi K, Li S, Dou X, Ning Y, Cheng G, Yang Q, Sang X, Peng M, Lyu Q, Wang L, Han X, Cao G
Acta pharmaceutica Sinica. B 2025 Apr;15(4):2059-2076

Potential mechanisms of aortic medial degeneration promoted by co-exposure to microplastics and lead.

Xie X, Wang K, Shen X, Li X, Wang S, Yuan S, Li B, Wang Z
Journal of hazardous materials 2024 Aug 15;475:134854

A glycometabolic gene signature associating with immune infiltration and chemosensitivity and predicting the prognosis of patients with osteosarcoma.

Wang F, Yang K, Pan R, Xiang Y, Xiong Z, Li P, Li K, Sun H
Frontiers in medicine 2023;10:1115759

Inhibition of ANXA2 activity attenuates epileptic susceptibility and GluA1 phosphorylation.

Ma L, Wu Q, Yuan J, Wang Y, Zhang P, Liu Q, Tan D, Liang M, Chen Y
CNS neuroscience & therapeutics 2023 Nov;29(11):3644-3656

Pseudoephedrine Nanoparticles Alleviate Adriamycin-Induced Reproductive Toxicity Through the GnRhR Signaling Pathway.

Fu Y, Yuan P, Zheng Y, Wei Y, Gao L, Ruan Y, Chen Y, Li P, Feng W, Zheng X
International journal of nanomedicine 2022;17:1549-1566

Ephedra herb reduces adriamycin-induced testicular toxicity by upregulating the gonadotropin-releasing hormone signalling pathway.

Fu Y, Yuan P, Zheng Y, Gao L, Wei Y, Chen Y, Li P, Ruan Y, Zheng X, Feng W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jun;150:113061

Dynamic Alteration Profile and New Role of RNA m6A Methylation in Replicative and H(2)O(2)-Induced Premature Senescence of Human Embryonic Lung Fibroblasts.

Wu F, Zhang L, Lai C, Peng X, Yu S, Zhou C, Zhang B, Zhang W
International journal of molecular sciences 2022 Aug 17;23(16)

MicroRNA-384 Inhibits the Progression of Papillary Thyroid Cancer by Targeting PRKACB.

Wang Y, Wang B, Zhou H, Zhang X, Qian X, Cui J
BioMed research international 2020;2020:4983420

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HT-1080 cells were subjected to SDS PAGE followed by western blot with 12232-1-AP(PRKACB antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of Hela cells, using PRKACB antibody 12232-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human medulloblastoma using 12232-1-AP(PRKACB antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue