BS8469

antibody from Bioworld Technology, Inc
Targeting: PRKACB PKACb
Provider product page for BS8469
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS8469 - Provider product page
Provider
Bioworld Technology, Inc
Product name
PKAÉÇ cat polyclonal antibody
Antibody type
Polyclonal
Antigen
cAMP-dependent protein kinase catalytic subunit beta; PRKACB; PKA C beta; PKA C-beta; PKACB; PKA CÉÇ
Description
Activation of PKA occurs when cAMP binds to the two regulatory subunits of the tetrameric PKA holoenzyme resulting in release of active catalytic subunits. Three catalytic (C) subunits have been identified, designated CÏ«, CÉÇ and CÎÛ, that each represent specific gene products. CÏ« and CÉÇ are closely related (93% amino acid sequence similarity), whereas CÎÛ displays 83% and 79% similarity to CÏ« and CÉÇ, respectively. Activation of transcription upon elevation of cAMP levels results from translocation of PKA to the nucleus where it phosphorylates the transcription factor cAMP response element binding protein (CREB) on serine 133 which in turn leads to TFIIB binding to TATA-box-binding protein TBP1, thus linking phospho-CREB to the Pol II transcription initiation complex.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PRKACB protein structure - BS8469 shown in red.