55382-1-AP

antibody from Proteintech Group

Targeting: PRKACB PKACb

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

55382-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#55382-1-AP, RRID:AB_10949078

Product name

PKA C-beta-specific antibody

Antibody type

Polyclonal

Description

PKA C-beta-specific antibody (Cat. #55382-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Epimedium brevicornum Maxim and Ligustrum lucidum Ait enhance glucocorticoid-associated anti-inflammatory effects in asthma via the cAMP/PKA/CREB signaling pathway.

Ma Z, Zhao Z, Liu R, Xie Y, Ma Z, Li Y, Long Y, Tang X
Journal of ethnopharmacology 2026 May 10;362:121259

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Loss of PRKACB facilitates metastasis of diffuse-type gastric cancer through RhoA signaling activation.

Sun J, Zhao J, Yang X, Tian C, Ji C, Liu J, Nomura S, Ruan Y, Wang X, Li H
Cell death & disease 2026 Mar 18;17(1)

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Integrating neurotrophic and anti-inflammatory pathways: press-needle acupuncture as a multi-target therapy for adolescent depression.

Zhang H, Rong Y, Ning R, Yan Z, Zhao Y, Chen Y
The International journal of neuroscience 2026 Mar 12;:1-16

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Astragaloside IV alleviates post-traumatic cytotoxic edema via inhibition of AQP4 expression and subcellular localization.

Shen W, Jiang C, Liu X, Wang D, Li G, Hui Y, Ding Y, Li C, Shao B, Hou B
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158096

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Psoralen Promotes Direct Chemical Reprogramming of Mouse Embryonic Fibroblasts into Osteoblast-like Cells.

Li W, Liu H, Wan X, Cheng D, Zhu R, Zhang Z
Pharmaceutics 2026 Feb 23;18(2)

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Nonthermal radiofrequency radiation promotes hematopoietic stem and progenitor cells function by regulating Ca(2+) efflux.

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Stem cell research & therapy 2026 Feb 14;17(1)

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Elevated Bile Acids Induce Circadian Rhythm Sleep Disorders in Chronic Liver Diseases.

Zhou L, Yan M, Luo Q, Qiu W, Guo YR, Guo XQ, Yu HB, Huo JR, Feng YL, Wang DP, Sun T, Wang KF, Shi JY, Shang X, Wu MN, Wang L, Cao JM
Cellular and molecular gastroenterology and hepatology 2025;19(3):101439

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High mobility group box 1, a novel serotonin receptor-7 negative modulator, contributes to M2 microglial ferroptosis and neuroinflammation in post-stroke depression.

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Free radical biology & medicine 2025 Sep;237:666-683

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β-Eudesmol in Rhizoma Atractylodis targets AVPR2 to inhibit the cAMP-AQP2 pathway and promote fluid metabolism.

Ke C, Zhong L, Yao D, Nie W, Xiao Y, Qu L, Liu Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157035

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Linarin alleviates high-fat diet-induced hepatic steatosis by inhibiting PDE4D and activating the cAMP/PKA/CREB pathway.

Xiao Y, Wang J, Zhang H, Yang X, Zhou J, Zhou Y, Liu S, Liu M, Wang Y, Wang Y, Liao Q, Hou M, Hao Y, Liu S, Luo Z, Zhang S, Yu J, Yu L, Zhou L, Li Y, Li G
Free radical biology & medicine 2025 Nov;239:116-129

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Sweroside, the effective component of jianwei shoutai pills, alleviates recurrent pregnancy loss by activating cAMP signaling pathway in maternal-fetal interface.

Zeng L, Huang X, Chen T, Yu Z, Huang C, Xia B, Huang X, Li K, Li J, Luo S, Gao J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157427

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Semaglutide and High-Intensity Interval Exercise Attenuate Cognitive Impairment in Type 2 Diabetic Mice via BDNF Modulation.

Lai S, Kang Z, Sun J, Wang Z, Xu Y, Xing S, Feng M, Wang Y, Liu H
Brain sciences 2025 May 1;15(5)

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F-box protein FBXO21 overexpression inhibits the proliferation and metastasis of clear cell renal cell carcinoma and is closely related to the CREB pathway and tumor immune cell infiltration.

Yang W, Jing T, Wu C, Lu M, Yao X, Xia D, Peng D
Journal of translational medicine 2025 Mar 15;23(1):335

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Dissecting the neuronal mechanisms of pinoresinol against methamphetamine addiction based on network and experimental pharmacology.

Fan S, Qi Y, Zhang F, Shi Y, Ma K, Pan Q, Jiang A, He L, Zhang J, Ma T, Zhou L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156322

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The β2-adrenergic receptor modulates activity of porcine alveolar macrophages in response to Actinobacillus pleuropneumoniae infection.

Xing W, Shi H, Wu W, Lu S, Fu H, Lu J, Li S, Xu B
Developmental and comparative immunology 2025 Aug;169:105420

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Mesenchymal stem cells in tumor microenvironment: drivers of bladder cancer progression through mitochondrial dynamics and energy production.

Yang E, Jing S, Wang F, Wang H, Fu S, Yang L, Tian J, Golijanin DJ, El-Deiry WS, Cheng L, Wang Z
Cell death & disease 2024 Sep 20;15(9):688

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Olanzapine suppresses mPFC activity-norepinephrine releasing to alleviate CLOCK-enhanced cancer stemness under chronic stress.

Lu J, Zhang X, Su K, Luo H, Liu C, Yang Y, He B, Wang C, Zhao Z, Liu X, Wang X, Meng P, Lv D, Wang C, Kelley KW, Wang L, Cui B, Liu Q, Peng F
Cell communication and signaling : CCS 2024 Jul 25;22(1):375

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Regulatory Effects and Mechanisms of L-Theanine on Neurotransmitters via Liver-Brain Axis Under a High Protein Diet.

Xu W, Song Y, Xiao W, Gong Z
Molecular neurobiology 2024 Feb;61(2):783-798

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Buyang huanwu decoction improves synaptic plasticity of ischemic stroke by regulating the cAMP/PKA/CREB pathway.

Mo J, Liao W, Du J, Huang X, Li Y, Su A, Zhong L, Gong M, Wang P, Liu Z, Kuang H, Wang L
Journal of ethnopharmacology 2024 Dec 5;335:118636

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McCune-Albright syndrome associated with pituitary adenoma: a clinicopathological study of ten cases and literature review.

Li Z, Liu R, Liu P
British journal of neurosurgery 2024 Aug;38(4):867-876

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GTPBP8 modulates mitochondrial fission through a Drp1-dependent process.

He X, Wang L, Tsang HY, Liu X, Yang X, Pu S, Guo Z, Yang C, Wu Q, Zhou Z, Cen X, Zhao H
Journal of cell science 2024 Apr 15;137(8)

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The delta subunit of the GABA(A) receptor is necessary for the GPT2-promoted breast cancer metastasis.

Li N, Xu X, Liu D, Gao J, Gao Y, Wu X, Sheng H, Li Q, Mi J
Theranostics 2023;13(4):1355-1369

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Protective Effects of ζ-Carotene-like Compounds against Acute UVB-Induced Skin Damage.

Zhang L, Liang S, Zhang Z, Wang K, Cao J, Yao M, Qin L, Qu C, Miao J
International journal of molecular sciences 2023 Sep 12;24(18)

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Mitoguardin2 Is Associated With Hyperandrogenism and Regulates Steroidogenesis in Human Ovarian Granulosa Cells.

Yan MQ, Wang Y, Wang Z, Liu XH, Yang YM, Duan XY, Sun H, Liu XM
Journal of the Endocrine Society 2023 Mar 6;7(5):bvad034

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ICP4-Associated Activation of Rap1b Facilitates Herpes Simplex Virus Type I (HSV-1) Infection in Human Corneal Epithelial Cells.

Zhang B, Ding J, Ma Z
Viruses 2023 Jun 27;15(7)

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Exposure to dithiocarbamate fungicide maneb in vitro and in vivo: Neuronal apoptosis and underlying mechanisms.

Liu C, Liu Z, Fang Y, Liao Z, Zhang Z, Yuan X, Yu T, Yang Y, Xiong M, Zhang X, Zhang G, Meng L, Zhang Z
Environment international 2023 Jan;171:107696

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Negative Feedback of the cAMP/PKA Pathway Regulates the Effects of Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome Activation on Type II Alveolar Epithelial Cell Pyroptosis as a Novel Mechanism of BLM-Induced Pulmonary Fibrosis.

Hong Q, Zhang Y, Lin W, Wang W, Yuan Y, Lin J, Xie Z, Li X, Meng Y
Journal of immunology research 2022;2022:2291877

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Different lipid metabolic profiles and their associated genes in sessile serrated adenoma or polyps compared to hyperplastic polyps.

Tang C, Li J, Yang Z, Chen Y, Zeng C
American journal of cancer research 2022;12(5):1982-1994

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Cannabidiol attenuates methamphetamine-induced cardiac inflammatory response through the PKA/CREB pathway in rats.

Nie Q, Dong W, Shen B, Yang G, Yu H, Zhang R, Peng Y, Yu Y, Hong S, Li L
Annals of translational medicine 2022 Sep;10(18):985

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H3F3A K27M Mutation Promotes the Infiltrative Growth of High-Grade Glioma in Adults by Activating β-Catenin/USP1 Signaling.

Sun Z, Zhu Y, Feng X, Liu X, Zhou K, Wang Q, Zhang H, Shi H
Cancers 2022 Oct 3;14(19)

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GSK3β palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2-STAT3 axis.

Zhao C, Yu H, Fan X, Niu W, Fan J, Sun S, Gong M, Zhao B, Fang Z, Chen X
Oncogenesis 2022 May 23;11(1):28

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Per1/Per2 Disruption Reduces Testosterone Synthesis and Impairs Fertility in Elderly Male Mice.

Liu Q, Wang H, Wang H, Li N, He R, Liu Z
International journal of molecular sciences 2022 Jul 2;23(13)

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Quercetin, Engelitin and Caffeic Acid of Smilax china L. Polyphenols, Stimulate 3T3-L1 Adipocytes to Brown-like Adipocytes Via β3-AR/AMPK Signaling Pathway.

Kong L, Zhang W, Liu S, Zhong Z, Zheng G
Plant foods for human nutrition (Dordrecht, Netherlands) 2022 Dec;77(4):529-537

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Total barley maiya alkaloids inhibit prolactin secretion by acting on dopamine D2 receptor and protein kinase A targets.

Gong X, Tao J, Wang Y, Wu J, An J, Meng J, Wang X, Chen Y, Zou J
Journal of ethnopharmacology 2021 Jun 12;273:113994

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Uncaria rhynchophylla ameliorates unpredictable chronic mild stress-induced depression in mice via activating 5-HT(1A) receptor: Insights from transcriptomics.

Qiao YL, Zhou JJ, Liang JH, Deng XP, Zhang ZJ, Huang HL, Li S, Dai SF, Liu CQ, Luan ZL, Yu ZL, Sun CP, Ma XC
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;81:153436

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Hypericin attenuates nonalcoholic fatty liver disease and abnormal lipid metabolism via the PKA-mediated AMPK signaling pathway in vitro and in vivo.

Liang C, Li Y, Bai M, Huang Y, Yang H, Liu L, Wang S, Yu C, Song Z, Bao Y, Yi J, Sun L, Li Y
Pharmacological research 2020 Mar;153:104657

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Label-Free Quantitative Phosphoproteomics Reveals Regulation of Vasodilator-Stimulated Phosphoprotein upon Stathmin-1 Silencing in a Pair of Isogenic Colorectal Cancer Cell Lines.

Tan HT, Chung MCM
Proteomics 2018 Apr;18(8):e1700242

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

mouse brain tissue were subjected to SDS PAGE followed by western blot with 55382-1-AP(PRKACB antibody) at dilution of 1:500

Sample type

tissue

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The PRKACB antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human PRKACB. This antibody recognizes human,mouse,rat antigen. The PRKACB antibody has been validated for the following applications: ELISA, WB, IHC analysis.

Appendix

55382-1-AP.pdf

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