BCL2A1

gene product
ACC-1, ACC-2, ACC1, ACC2, BCL2L5, BFL1, GRS, HBPA1
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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Antibodies

 

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Antibodypedia Validation Initiative

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383 antibodies from 38 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
119 antibodies
GeneTex
5 antibodies
Novus Biologicals
22 antibodies
Invitrogen Antibodies
5 antibodies
Biorbyt
24 antibodies
Aviva Systems Biology
4 antibodies
OriGene
12 antibodies
Abnova Corporation
8 antibodies
Abgent
9 antibodies
Acris Antibodies GmbH
14 antibodies
Rockland Immunochemicals, Inc.
2 antibodies
LifeSpan BioSciences, Inc.
36 antibodies
ProSci
4 antibodies
St John's Laboratory
4 antibodies
Boster Biological Technology
2 antibodies
Affinity Biosciences
1 antibody
Proteintech Group
1 antibody
R&D Systems
1 antibody
Santa Cruz Biotechnology
1 antibody
Antibodies.com
2 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Cell Signaling Technology, Inc
1 antibody
NovoPro Bioscience Inc.
1 antibody
NSJ Bioreagents
2 antibodies
RabMAbs
2 antibodies
Creative Diagnostics
5 antibodies
Creative Biolabs
1 antibody
Everest Biotech
1 antibody
MyBioSource
8 antibodies
United States Biological
56 antibodies
EMD Millipore
2 antibodies
Abbiotec
2 antibodies
Bioworld Technology, Inc
1 antibody
RayBiotech, Inc.
3 antibodies
Sigma-Aldrich
5 antibodies
Abbexa
3 antibodies
GenWay
1 antibody