CASP8AP2

This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Nov 2008]

Description

Caspase 8 associated protein 2

Tissue specificity

Tissue enhanced (brain)

Subcell location

Nucleoli, Nuclear bodies

Predicted location

Intracellular

Protein family

Predicted intracellular proteins

Chromosome

6 (89829894 - 89874436)

Ensembl ID

ENSG00000118412  (ver. 103.38)

Orthologs

Mouse Casp8ap2: ENSMUSG00000028282

UniProt

 

neXtProt

 

Human splice variants
Mouse splice variants

Protein structure