TFAP2B

This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives. [provided by RefSeq, Jul 2008]

Description

transcription factor AP-2 beta

Protein family

Cancer-related genes, Disease related genes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted intracellular proteins, Protein evidence (Peptideatlas), Transcription factors

Chromosome

6:p12.3 (50818723 - 50847619)

Ensembl ID

ENSG00000008196  (ver. 99.38)

Orthologs

Mouse Tfap2b: ENSMUSG00000025927

UniProt

Q92481

neXtProt

NX_Q92481

Human splice variants
Mouse splice variants