Antibody data

Product number
Ab095764 - Provider product page
Provider
Aladdin Scientific
Product name
Cdk4 Antibody
Antibody type
Polyclonal
Description
Rabbit anti Human Cdk4 Antibody, Polyclonal, could be used for WB, IHC and so on. Application WB: 0.01-2 µg/mL IHC: 5-20 µg/mL Protein Function Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Conjugate
Unconjugated
Antigen sequence
AA 6-295
Vial size
100_l,10_l,1ml,20_l,50_l
Concentration
Lot by Lot
Storage
Store at 4_ short term (1-2 weeks). Store at -20_ long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
CDK4 protein structure - Ab095764 shown in red.