CDK4

gene product
PSK-J3
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
1026 antibodies from 43 providers.

Antibody properties

General

Applications

or Cancel
Antibody
Invitrogen Antibodies
14 antibodies
GeneTex
17 antibodies
antibodies-online
356 antibodies
NovoPro Bioscience Inc.
1 antibody
Novus Biologicals
32 antibodies
Abnova Corporation
19 antibodies
Biorbyt
36 antibodies
Abgent
7 antibodies
OriGene
16 antibodies
NSJ Bioreagents
7 antibodies
Proteintech Group
1 antibody
Aviva Systems Biology
5 antibodies
Cell Signaling Technology, Inc
3 antibodies
R&D Systems
1 antibody
LifeSpan BioSciences, Inc.
243 antibodies
ProSci
6 antibodies
Bioworld Technology, Inc
2 antibodies
Boster Biological Technology
4 antibodies
St John's Laboratory
7 antibodies
Affinity Biosciences
3 antibodies
Bethyl Laboratories
2 antibodies
Signalway Antibody LLC
2 antibodies
Acris Antibodies GmbH
17 antibodies
Santa Cruz Biotechnology
1 antibody
Abbkine Scientific Co.Ltd.
1 antibody
BioLegend
3 antibodies
RabMAbs
8 antibodies
Creative Diagnostics
13 antibodies
MyBioSource
21 antibodies
Creative Biolabs
55 antibodies
GenWay
9 antibodies
EMD Millipore
3 antibodies
Arigo
1 antibody
Atlas Antibodies
1 antibody
United States Biological
67 antibodies
Abbiotec
3 antibodies
RayBiotech, Inc.
2 antibodies
Enzo Life Sciences
1 antibody
Rockland Immunochemicals, Inc.
1 antibody
Abbexa
4 antibodies
Sigma-Aldrich
5 antibodies
Exalpha Biologicals, Inc.
2 antibodies