CYP26A1

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

Description

Cytochrome P450 family 26 subfamily A member 1

Tissue specificity

Tissue enriched (liver)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

10 (93073475 - 93077885)

Ensembl ID

ENSG00000095596  (ver. 103.38)

Orthologs

Mouse Cyp26a1: ENSMUSG00000024987

UniProt

O43174

neXtProt

NX_O43174

Human splice variants
Mouse splice variants

Protein structure