ANK1

gene product
ANK, SPH1
Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. [provided by RefSeq, Dec 2008]
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186 antibodies from 26 providers.

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Novus Biologicals
9 antibodies
LifeSpan BioSciences, Inc.
30 antibodies
Biorbyt
40 antibodies
antibodies-online
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Invitrogen Antibodies
3 antibodies
Abnova Corporation
7 antibodies
Aviva Systems Biology
4 antibodies
OriGene
3 antibodies
Atlas Antibodies
2 antibodies
Santa Cruz Biotechnology
1 antibody
GeneTex
2 antibodies
Bethyl Laboratories
1 antibody
MyBioSource
5 antibodies
EMD Millipore
1 antibody
NovoPro Bioscience Inc.
1 antibody
Creative Diagnostics
5 antibodies
Sigma-Aldrich
3 antibodies
UC Davis/NIH NeuroMab Facility
3 antibodies
Abbiotec
1 antibody
Acris Antibodies GmbH
1 antibody
Abgent
2 antibodies
Everest Biotech
1 antibody
GenWay
1 antibody
United States Biological
12 antibodies
ProSci
1 antibody