CIITA

gene product
C2TA, MHC2TA, NLRA
This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the ""master control factor"" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
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168 antibodies from 31 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
4 antibodies
GeneTex
5 antibodies
Invitrogen Antibodies
3 antibodies
antibodies-online
59 antibodies
LifeSpan BioSciences, Inc.
18 antibodies
OriGene
10 antibodies
Santa Cruz Biotechnology
1 antibody
Biorbyt
17 antibodies
Abgent
3 antibodies
Affinity Biosciences
1 antibody
ProSci
1 antibody
Abnova Corporation
4 antibodies
NSJ Bioreagents
1 antibody
Acris Antibodies GmbH
8 antibodies
Boster Biological Technology
3 antibodies
Cell Signaling Technology, Inc
1 antibody
Aviva Systems Biology
4 antibodies
Rockland Immunochemicals, Inc.
3 antibodies
MyBioSource
3 antibodies
GenWay
3 antibodies
Creative Biolabs
4 antibodies
Abiocode, Inc.
1 antibody
RabMAbs
1 antibody
RayBiotech, Inc.
1 antibody
Creative Diagnostics
2 antibodies
Abbiotec
1 antibody
Abbkine Scientific Co.Ltd.
1 antibody
EMD Millipore
1 antibody
St John's Laboratory
1 antibody
United States Biological
1 antibody
Sigma-Aldrich
2 antibodies