CD1D

This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

Description

CD1d molecule

Tissue specificity

Group enriched (intestine, liver, lymphoid tissue)

Subcell location

Endoplasmic reticulum

Predicted location

Membrane

Protein family

Cancer-related genes
CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

1 (158178030 - 158186427)

Ensembl ID

ENSG00000158473  (ver. 103.38)

Orthologs

-

UniProt

P15813

neXtProt

NX_P15813

Human splice variants

Protein structure