CYP2C9

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]

Description

Cytochrome P450 family 2 subfamily C member 9

Tissue specificity

Tissue enriched (liver)

Subcell location

Vesicles, Plasma membrane

Predicted location

Intracellular

Protein family

Enzymes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

10 (94938658 - 94990091)

Ensembl ID

ENSG00000138109  (ver. 103.38)

Orthologs

-

UniProt

P11712

neXtProt

NX_P11712

Human splice variants

Protein structure