680502

antibody from BioLegend

Targeting: IGFALS ALS

Antibody data

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Validation data

Product number: 680502 - Provider product page
Provider: BioLegend
Proper citation: BioLegend Cat#680502, RRID:AB_2566383
Product name: Purified anti-IGFALS (ALS)
Antibody type: Monoclonal
Antigen: Recombinant human IGFALS
Description: Insulin-like growth factor-binding protein complex acid labile subunit (ALS) is an 85 kD glycoprotein that is produced almost exclusively by the liver and secreted into circulation. The protein surface contains charged residues, which together with the negatively charged N-linked glycosylation on the ALS protein, provides the necessary electrostatic potential to interact with the IGF-I-IGFBP-3 binary complex. The well-established function of ALS is to prolong the half-lives of the IGF-IGFBP-3/IGFBP-5 binary complexes.In rodents, genetic targeted ablation of the IGFALS gene appeared to increase sensitivity to insulin. In humans, mutations in IGFALS caused ALS deficiency, an autosomal recessive condition featured by a marked reduction in circulating levels of both IGF-I and IGFBP-3. Subjects with ALS deficiency are short and, usually accompanied by compensatory elevated levels of GH. In rare cases, pubertal delay, insulin resistance, and immunological dysfunction were also found.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Antibody clone number: M6005H11
Vial size: 100 µg
Concentration: 0.5 mg/ml
Storage: 2°C-8°C
Handling: Ambient RT

IGFALS protein structure - 680502 shown in red.