IGFALS

The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Description

insulin like growth factor binding protein acid labile subunit

Protein family

Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014)

Chromosome

16:p13.3 (1790413 - 1794971)

Ensembl ID

ENSG00000099769  (ver. 84.38)

Orthologs

Mouse Igfals: ENSMUSG00000046070

UniProt

P35858

neXtProt

NX_P35858

Human splice variants
Mouse splice variants