Antibody data

Product number
Ab106628 - Provider product page
Provider
Aladdin Scientific
Product name
Recombinant GSK3 beta Antibody
Antibody type
Recombinant
Description
Rabbit anti Human GSK3 beta Antibody, Recombinant (R09-7G8), could be used for WB, IHC and so on.ApplicationWB: 1/500-1/1000IHC: 1/50-1/100Protein FunctionParticipates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Phosphorylates MACF1 and this phosphorylation inhibits the binding of MACF1 to microtubules which is critical for its role in bulge stem cell migration and skin wound repair.
Reactivity
Human, Mouse, Rat, Hamster
Host
Rabbit
Conjugate
Unconjugated
Antigen sequence
AA 1-13
Antibody clone number
R09-7G8
Vial size
100μl,10μl,1ml,50μl
Concentration
0,5 mg/ml
Storage
Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
GSK3B protein structure - Ab106628 shown in red.